SPATIAL PROCESSING IN AUDITORY CORTEX

描述：（改编自申请人的摘要。）拟议的研究 将使用两耳分听和自由场刺激相结合的方法来检查 单个神经元的双耳响应特性，并确定这些如何 响应特性塑造了它们的声音位置选择性。 记录 将标记这些部位以确定这些神经元是否在解剖学上 相对于双耳特性或空间调谐来组织。 径向 穿透皮质柱将决定 响应属性在单个列中。 皮层表面将 以确定听觉类型是否在解剖学上 分离，以及是否在每个听觉分离存在一个更好的 职能组织的层次。 结果将与类似的 研究下丘以研究反应的转化 从中脑到皮层水平的性质和功能组织。 皮质60 kHz区域的功能分区将注射 逆行示踪剂，以确定连接的特异性 皮质和皮质下结构。

DESCRIPTION: (Adapted from the Applicant's Abstract.) The proposed studies will use a combined dichotic and free-field stimulation method to examine binaural response properties of single neurons, and determine how these response properties shape their sound location selectivity. Recording sites will be marked to determine if these neurons are anatomically organized with respect to binaural properties or spatial tuning. Radial penetrations through cortical columns will determine the homogeneity of response properties in a single column. The cortical surface will be mapped in two dimensions to determine whether aural types are anatomically segregated, and whether within each aural segregation there exists a finer level of functional organization. Results will be compared with similar studies of the inferior colliculus to study the transformation of response properties and functional organization from the midbrain to cortical level. Functional subdivisions of the cortical 60 kHz region will be injected with retrograde tracers to determine the specificity of connections with cortical and subcortical structures.