ROLE OF CATECHOLAMINES IN THE INITIATION OF LABOR

儿茶酚胺在分娩过程中的作用

• 批准号: 3469460
• 负责人: Charles A Ducsay
• 金额: $ 13.34万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3469460
• 关键词: Macaca mulatta; amnion; amniotic fluid; antiadrenergic agents; birth; blood chemistry; catecholamines; catheterization; chorioallantoic membrane; circadian rhythms; dopamine; epinephrine; fatty acid biosynthesis; gestational age; high performance liquid chromatography; hormone regulation /control mechanism; muscle contraction; myometrium; norepinephrine; premature infant animal; premature labor; prostaglandin F; radioimmunoassay; statistics /biometry

Premature birth is one of the principal causes of perinatal morbidity and mortality. In order of to aid in the understanding and prevention of this problem, it is imperative to elucidate the factors involved in the regulation of myometrial contractility and the initiation of parturition. Due to ethical considerations, data obtained from human studies are incomplete. This proposal will examine the role of CATS in the initiation of labor by studying the qualitative and quantitative changes in CAT concentrations in the chronically catheterized rhesus monkey. Studies will include measurements of epinephrine, and dopamine in maternal and fetal plasma and amniotic fluid. In addition, PG concentrations (PGEM-II, PGFM, and 6-keto-PGF1alpha) will be quantitated. How these changes are related to alterations in uterine activity and the initiation of labor will also be assessed. In vitro superfusion studies will examine the interaction between CATS and PGs in reproductive tissues collected from pregnant rhesus monkeys. Specifically, what are the stimulatory effects of CATS on PG biosynthesis by decidua, myometrium, amnion, and chorion? PG (PGF2, PGE2 and 6-keto-PGF1alpha) production will be quantitated before and after exposure of the tissue to CATs. These studies will be directed to answer the following questions: 1) Is there a causal relationship between changes in CATS and uterine activity rhythms? 2) Do CATs exert their effects indirectly by first stimulating PG biosynthesis? These studies are in line with the long-term goals of the present research program, namely, to clarify the mechanisms involved in the regulation of uterine contractility and the initiation of labor.

早产是围产期的主要原因之一

项目成果

Regulation of cell-cell communication mediated by connexin 43 in rabbit myometrial cells.

兔子宫肌细胞中连接蛋白 43 介导的细胞间通讯的调节。

• DOI: 10.1095/biolreprod50.2.377
• 发表时间: 1994
• 期刊: Biology of reproduction
• 影响因子: 3.6
• 作者: Nnamani,C;Godwin,A;Ducsay,CA;Longo,LD;Fletcher,WH
• 通讯作者: Fletcher,WH

Circadian rhythms during pregnancy.

• DOI: 10.1210/edrv-14-5-594
• 发表时间: 1993-10
• 期刊: Endocrine reviews
• 影响因子: 20.3
• 作者: M. Seron-Ferre;C. Ducsay;G. Valenzuela

Myometrial contractile responsiveness to oxytocin after dexamethasone suppression of circadian uterine activity in pregnant rhesus macaques during late gestation.

怀孕后期地塞米松抑制妊娠恒河猴昼夜节律子宫活动后，子宫肌层收缩对催产素的反应。

• DOI: 10.1016/0002-9378(92)91754-x
• 发表时间: 1992
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Ducsay,CA;Ervin,MG;Kaushal,KM;Matsumoto,T
• 通讯作者: Matsumoto,T

Acute intrauterine hypoxia increases amniotic fluid prostaglandin F metabolites in the pregnant sheep.

急性宫内缺氧使妊娠羊羊水中前列腺素F代谢物增加。

• DOI: 10.1016/s0002-9378(11)91733-5
• 发表时间: 1992
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Valenzuela,GJ;Norburg,M;Ducsay,CA
• 通讯作者: Ducsay,CA

Catecholamines and uterine activity rhythms in the pregnant rhesus macaque.

怀孕恒河猴的儿茶酚胺和子宫活动节律。

• DOI: 10.1095/biolreprod45.2.373
• 发表时间: 1991
• 期刊: Biology of reproduction
• 影响因子: 3.6
• 作者: McNutt,CM;Ducsay,CA
• 通讯作者: Ducsay,CA