THE INTERPOSITUS NUCLEUS AND CLASSICAL NM CONDITIONING

学习和记忆方面的障碍，即使是最简单的 任务可能会对正常运行造成极大的破坏，而且在 从长远来看，会影响心理和身体健康。充分地 了解学习和记忆障碍，有必要 了解大脑如何改变活动以产生学习和 记忆。为此，拟议研究的长期目标是 是描述神经机制和过程，形成 基础是简单形式的学习和记忆。更确切地说， 被提议的实验被设计用来研究参与 小脑深核(即间位核) 经典的条件反射，一种简单的运动学习形式。三 提出了实验的阶段：1)表征 关键部位的模式输入到间位核， 2)对可能发生的活动变化的描述 经典条件反射中的间位核，3) 开发一种面向未来的减量制剂 经典型神经损伤相关神经机制的细胞内研究 条件反射。在拟议的实验的所有三个阶段， 黄曲霉毒素诱发的胞外场电位和单位活性 将监测小脑前部传入的刺激以评估 错位活跃性。预计这些研究将 提供有关代替物活性的有价值的数据 经典条件反射过程中的细胞核。

Impairments in the learning and memory of even the simplest of tasks can be extremely disruptive to normal functioning and, in the long term, affect both mental and physical health. To fully understand impairments of learning and memory, it is necessary to understand how the brain alters activity to produce learning and memory. To this end, the long term goal of the proposed research is to described neuronal mechanisms and processes that form the basis of simple forms of learning and memory. More specifically, the proposed experiments are designed to study of the involvement the cerebellar deep nuclei (i.e., the interpositus nucleus) in classical conditioning, a simple form of motor learning. Three phases of experimentation are proposed: 1) a characterization of the patterns of critical sitmulus inputs the interpositus nucleus, 2) a description of potential alterations of activity of the interpositus nucleus during classical conditioning, 3) the development of a reduced preparation amenale to future intracellular study of neuronal mechanisms involved in classical conditioning. In all three phases of the proposed experimentation, extracellular field potentials and single unit acitivity evoked by stimulation of precerebellar afferents will be monitored to assess imterpositus activity. It is anticipated that these studies will provide valuable data concerning activity of the interpositus nucleus during classical conditioning.