THE INTERPOSITUS NUCLEUS AND CLASSICAL NM CONDITIONING

即使是最简单的人， 任务可能会极大地破坏正常运作， 长期下去，会影响身心健康。 充分 了解学习和记忆障碍，有必要 了解大脑如何改变活动以产生学习， 记忆 为此，提出了研究的长期目标， 是描述神经机制和过程，形成 简单形式的学习和记忆的基础。 更具体地说， 所提出的实验旨在研究参与 小脑深核（即，间位核） 经典条件反射是运动学习的一种简单形式 三 提出了实验的阶段：1）表征 临界情境的模式输入中间核， 2)对活动的潜在变化的描述 在经典条件反射过程中的中间核，3） 发展一种减少准备amenale未来 神经元机制的细胞内研究 条件反射 在拟议实验的所有三个阶段中， 诱发的细胞外场电位和单位活动 将监测小脑前传入神经的刺激， 间接活动 预计这些研究将 提供了有关间位体活动的宝贵数据 在经典条件作用下的核。

Impairments in the learning and memory of even the simplest of tasks can be extremely disruptive to normal functioning and, in the long term, affect both mental and physical health. To fully understand impairments of learning and memory, it is necessary to understand how the brain alters activity to produce learning and memory. To this end, the long term goal of the proposed research is to described neuronal mechanisms and processes that form the basis of simple forms of learning and memory. More specifically, the proposed experiments are designed to study of the involvement the cerebellar deep nuclei (i.e., the interpositus nucleus) in classical conditioning, a simple form of motor learning. Three phases of experimentation are proposed: 1) a characterization of the patterns of critical sitmulus inputs the interpositus nucleus, 2) a description of potential alterations of activity of the interpositus nucleus during classical conditioning, 3) the development of a reduced preparation amenale to future intracellular study of neuronal mechanisms involved in classical conditioning. In all three phases of the proposed experimentation, extracellular field potentials and single unit acitivity evoked by stimulation of precerebellar afferents will be monitored to assess imterpositus activity. It is anticipated that these studies will provide valuable data concerning activity of the interpositus nucleus during classical conditioning.