Engineering Blood Diagnostics: Integrated Platforms for Advanced Detection and Analysis

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We propose a research platform which will explore and underpin the development of new, integrative diagnostics based on a comprehensive analysis of blood. The integration of rheological and cytometric measurements is essential to the understanding of blood as a sophisticated tissue system in which biological mechanisms, initiated and controlled by cells, interact with complex fluid dynamics. The aim is to provide an appropriate technological platform which will provide biomarkers for the detection and analysis of pathological or therapeutic modifications of blood. These research aims demand multi-disciplinary skills, significant crossover of staff between academic and clinical environments and high risk, exploratory science - all aspects appropriate to the underpinning support of a platform grant.