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Engineering complex fluids in biology and medicine

生物学和医学中的工程复杂流体

基本信息

批准号：
EP/H024271/1
负责人：
Huw Summers
金额：
$ 25.68万
依托单位：
Swansea University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH024271%2F1
关键词：
Engineering complex fluids biology medicine

项目摘要

The proposed project will assess the feasibility of several complementary projects linked to a common theme: device and process engineering based on control and understanding of complex fluids. Resources will target three project areas: bio-processing, cytometry and cardio-vascular monitoring.These areas, while diverse in terms of their potential applications, have commonality in terms of fundamental aspects of complex fluid behaviour. All seek to engineer the complex properties of fluidic phenomena to produce devices to analyse or process biological materials such as cells, bacteria and tissue:1. The living laser - The 'living laser' will pass single cells through a micro-scale laser thus changing the lasing characteristics. This device is thus a hybrid biological/solid state device in which living cells become a part of the laser, because of the multiple passes of light around the laser cavity extremely sensitive optical interrogation of the cells can be achieved.2. Near-spinodal metastable fluid bio-processing - Nothing is presently known about the behaviour of even simple biological systems in liquids under near-spinodal conditions of negative pressure but known forms of bacteria and even viruses are unlikely to withstand brief exposure to such conditions without experiencing significant adverse effects, including pronounced rupture of cell walls and membranes. It is anticipated that few, if indeed any, forms of bacteria could remain viable following exposure to such conditions. We propose investigating the feasibility of generating near-spinodal levels of negative pressure within solutions of bacterial cells as a means of ensuring cell death and hence establishing the platform for a new technique for the sterilization of high value products.3. Cardiovascular devices - Patient specifc cardiovascular fluidic models of whole body arterial blood and air-flows have been developed. We will test the feasibility of using these models to develop new diagnostic device designs via reverse engineering approaches. These would involve preliminary architectures highlighting the major design issues and scoping the potential for detection of microstructural changes in the arterial system (stenosis and aneurysm) or pinpointing the location of a constriction at the lower human airway branches.

拟议的项目将评估与一个共同主题相关的几个互补项目的可行性：基于控制和理解复杂流体的设备和工艺工程。资源将针对三个项目领域：生物处理、细胞术和心血管监测。这些领域虽然在潜在应用方面各不相同，但在复杂流体行为的基本方面具有共性。所有人都试图设计流体现象的复杂特性，以生产分析或处理生物材料（如细胞、细菌和组织）的设备。活激光器——“活激光器”将使单个细胞通过微尺度激光器，从而改变激光特性。因此，该装置是一种生物/固体混合装置，其中活细胞成为激光的一部分，由于激光腔周围的光多次通过，可以实现对细胞的极其敏感的光学探测。近spinodal亚稳态流体生物处理-目前对液体中简单生物系统在近spinodal负压条件下的行为一无所知，但已知形式的细菌甚至病毒不太可能承受短暂暴露在这种条件下而不经历显著的不利影响，包括细胞壁和细胞膜的明显破裂。可以预见的是，即使有，也很少有细菌能在暴露于这样的条件下存活。我们建议研究在细菌细胞溶液中产生接近脊柱水平的负压的可行性，作为确保细胞死亡的一种手段，从而为高价值产品的灭菌新技术建立平台。心血管装置-病人特定的全身动脉血液和空气流动的心血管流体模型已经开发。我们将测试使用这些模型通过逆向工程方法开发新的诊断设备设计的可行性。这些将包括初步的架构，突出主要的设计问题，确定检测动脉系统（狭窄和动脉瘤）微结构变化的潜力，或确定人体下气道分支收缩的位置。