LITHIUM-SELECTIVE ELECTRODES WITH POLYMERIC IONOPHORES

这项建议的目标是开发一种锂离子选择性 电极，主要用于临床测定 接受躁狂抑郁症治疗的患者中的锂。锂 目前可用的电极对锂的选择性不够 相对于钠。测定了这些电极的选择性 通过作为离子的有机分子的金属亲和力 聚合物膜中的载体。改进的锂离子载体将使 在聚合物膜中充当离子载体的分子。改进 锂离子载体将使全血分析自动化成为可能 操作员对血液产品的最低限度处理。相似的电极 因为钙、钠和钾已经在临床上使用。 分析器市场。拟议项目的主要目标是改善 最有前途的锂系列的锂选择性 通过共价将电离团连接到柔性乙烯上 氧化物和硅氧烷聚合物。电离团的这种共价吸附 到聚合物主链应该有助于减少聚集并改善 防止2：1络合物形成的锂/钠选择性 离子载体和钠。

The objective of this proposal is to develop a lithium ion-selective electrode, primarily for application to the clinical determination of lithium in patients undergoing therapy for manic depression. The lithium electrodes currently available are not sufficiently selective for lithium relative to sodium. The selectivity of these electrodes is determined by the metal affinities of organic molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable automated analysis of whole blood with minimal handling of blood products by the operator. Similar electrodes for calcium, sodium and potassium are already in use in the clinical analyzer market. The major goal of the proposed project is to improve the lithium selectivity of the most promising family of lithium ionophores by covalent attachment of the ionophores to flexible ethylene oxide and siloxane polymers. This covalent attachment of the ionophores to a polymer backbone should help reduce aggregation and improve the lithium/sodium selectivity by preventing the formation of 2:1 complexes of the ionophore and sodium.