CERVICAL CANCER DETECTION AND SCREENING (PHASE II)

宫颈癌检测和筛查（第二阶段）

• 批准号: 3506369
• 负责人: JAMES W BACUS
• 金额: $ 29.89万
• 依托单位: CELL ANALYSIS SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 1986-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3506369
• 关键词: artificial intelligence; cell nucleus; cervical /vaginal smear; cervix neoplasms; clinical biomedical equipment; computer assisted diagnosis; cytology; cytoplasm; image processing; mass screening; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; preneoplastic state

The objective of this research is to develop new and improved diagnostic instrumentation for cervical cancer detection and screening. The techniques employed are based upon high-resolution digital imaging technology. A 5-year study just completed has clarified and quantified, for the purposes of cytology automation, the concepts exploited in traditional human cervical cytology screening, i.e., the detection requirements of the Pap smear screening "system", the cell detection capabilities of trained cytotechnologists, and the interrelationship of these factors. In addition, these studies proved that state-of-the-art image processing detection of suspicious and abnormal cells is as good as, or better than, highly trained cytotechnologists. The research and development, herein (Phase II), is to further specific aspects of the computer software design and to develop the conceptual design of a feasible diagnostic instrument. The expected results from the Phase II development would be completed software algorithms and other system parameters in a specific design. The potential commercial application of this research is in the area of clinical laboratory instrumentation and testing. The public health benefits include: (1)\a potential increase in accuracy and reproducibility in the routine performance of the Pap test; (2)\a possibility of standardization from one screening laboratory to another; and (3)\the potential capability of a more ready availability of this test to the general public. (3)

这项研究的目的是开发新的和改进的诊断 用于宫颈癌检测和筛查的仪器。这个 采用的技术是基于高分辨率的数字成像 技术刚刚完成的一项为期5年的研究已经澄清和量化了， 为了细胞学自动化的目的， 传统的人类宫颈细胞学筛查，即检测 巴氏涂片筛查系统的要求，细胞检测 训练有素的细胞技术专家的能力，以及 这些因素。此外，这些研究证明，最先进的 对可疑和异常细胞的图像处理检测效果与 或者比训练有素的细胞技术专家更好。该研究和 发展，在这里(第二阶段)是为了进一步的具体方面 为计算机软件的设计和开发提供了一个可行的概念设计 诊断仪器。二期开发的预期结果 软件算法和其他系统参数将在 具体设计。这项研究的潜在商业应用是 在临床实验室仪器和检测领域。公众 健康方面的好处包括：(1)准确度和 巴氏试验常规性能的重复性；(2) 从一个筛查实验室到另一个实验室标准化的可能性； 以及(3)更容易获得此测试的潜在能力 对普通公众来说。(3)