QUANTITATION OF NEOPLASIA IN CANCER CHEMOPREVENTION

癌症化学预防中肿瘤的定量

• 批准号: 2010411
• 负责人: JAMES W BACUS
• 金额: $ 9.99万
• 依托单位: BACUS LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2010411
• 关键词: biomedical equipment development; cell sorting; chemoprevention; computer program /software; histology; human tissue; image processing; measurement; method development; morphology; neoplasm /cancer classification /staging; neoplastic growth; preneoplastic state

The objectives of this research are to perform the basic research into methods and instrumentation to quantitate the development of neoplasia in the context of cancer chemoprevention, using microscopic image analysis methodology. The expected results of Phase I are proof of concept and feasibility, the major design parameters of an instrument, and the confirmation of sample preparation techniques and software algorithm development needs. These results should provide guidelines to enable an instrument to be developed to rapidly and reliably quantitate the development of neoplasia, specifically for cancer chemoprevention testing. Methods of selection of relevant tissue areas for measurement, and improvement of accuracy, reliability and cost of current methods of testing chemopreventive agents are goals of this research. Quantitative measurement and definitions of such current subjective visual assessments as "nuclear grade", "carcinoma in situ" "preneoplastic intraeithelial neoplasia" and other morphologic categories used to assess the severity of microscopic premalignant specimens, will be developed in view of chemopreventive testing needs. PROPOSED COMMERCIAL APPLICATION: The immediate commercial applications of this research relate to selling the developed instrument to special testing laboratories to test the effectiveness of proposed chemopreventive agents, either in animal model studies or in Phase II clinical trials. The long term potential commercial application relates to reference laboratory testing of special "at risk" patient populations who may be using approved or recommended chemopreventive agents.

本研究的目的是对……进行基础研究