ACCELERATOR PRODUCTION OF EPITHERMAL NEUTRONS FOR BNCT

第二阶段计划的目标是建造和测试加速器 用于硼中子俘获治疗的基中子辐照装置 （BNCT）. 在第一阶段，使用7 Li（p，n）7 Be产生的中子束， BNCT的反应进行了研究。 蒙特-卡罗模拟结果 中子和光子在减速器中的传输， 使用体模设计了优化中子辐照端口。 这些 计算表明，慢化加速器产生的中子 梁是竞争力最好的目前可用的反应堆生产 剂量-深度分布、剂量率和剂量 混合物. 用4 mA、2.5MeV质子束在 李可以向大脑中线的肿瘤输送治疗剂量， 不到一个小时。 加速器中子源基于一种新的 目前正在开发的静电加速器技术 研究实验室。 串联级联的突出特点 加速器（TCA）具有体积小、功耗低、 提供能量高达几百万的多毫安质子流 电子伏特 规模、资本和运营成本以及设施 该加速器的要求与安装在 实验室或医院。 TCA和锂靶的设计 能够产生BNCT所需的高中子强度， 在第一阶段完成。 在第二阶段，加速器源将是 制造、表征并用于中子剂量测定实验。 是 预计该系统将提供一个多功能的，专用的中子 BNCT研究的来源。

The goal of the Phase II program is to construct and test an accelerator based neutron irradiation facility for boron neutron capture therapy (BNCT). In Phase I, the use of neutron beams producted by the 7Li(p,n)7Be reaction for BNCT was investigated. The result of Monte-Carlo simulations of neutron and photon transport in moderators and a brain-equivalent phantom were used to design an optimized neutron irradiation port. These calculations demonstrated that a moderated accelerator-produced neutron beam is competitive with the best currently available reactor-produced beams with regard to dose-depth distribution, dose rate and dose composition. The neutron flux produced by a 4 mA, 2.5 MeV proton beam on Li can deliver a therapeutic dose to a tumor at the midline of the brain in less than one hour. The accelerator neutron source is based on a new electrostatic accelerator technology currently being developed at Science Research Laboratory. The salient features of the Tandem Cascade Accelerator (TCA) are compactness, low power consumption and the ability to deliver multi-milliampere proton currents at energies up to several million electron volts. The size, capital and operating costs, and facility requirements for this accelerator are compatible with installation in a research laboratory or hospital. The design of a TCA and lithium target capable of producing the high neutron intensities required for BNCT was completed in Phase I. In Phase II, the accelerator source will be fabricated, characterized and used in neutron dosimetry experiments. It is anticipated that this system will provide a versatile, dedicated neutron source for BNCT research.