K ALFA DUAL-ENERGY X-RAY SOURCE FOR CORONARY ANGIOGRAPHY

提出了一种用于双能量减影的特征线X射线源 人冠状动脉中碘的小面积密度的成像。 该源码是根据K-alpha制作的，线条在旋转 用高能电子束轰击金属化合物靶。在第一阶段， 使用一种新的方法计算了来自各种靶结构的X射线光谱， 蒙特-卡罗电子-光子程序和双能成像模拟程序 被开发来计算图像信噪比的范围内， 碘和组织参数。计算表明，优化的 系统将能够成像2 mg/sqr。cm碘造影剂， 20克/平方米cm的组织，SNR=5，总成像时间为10 ms 此外，第一阶段设计的X射线源的成本和尺寸 与临床使用兼容。 在第二阶段，将进行原理验证实验，以验证 建议的X射线源的操作能力和限制。一 将建造原型电子加速器和靶组件， 用于对体模进行双能量减影成像实验。 将评价两种探测器配置。一个升级的加速器， 目标设计能够提供所需的高光子通量 将开发该技术的临床应用。

A characteristic-line x-ray source is proposed for dual-energy subtraction imaging of small areal densities of iodine in the human coronary arteries. The source is based on the production of the K-alpha, lines in a rotating metal compound target bombarded by a high energy electron beam. In Phase 1, x-ray spectra from various target configurations were calculated using a Monte-Carlo electron-photon code and a dual-energy imaging simulation code was developed to calculate image signal-to-noise ratio for a range of iodine and tissue parameters. The calculations indicate that an optimized system would be capable of imaging 2 mg/sqr. cm of iodine contrast agent in 20 g/sqr. cm of tissue with a SNR=5 and a total imaging time of 10 ms. In addition, the cost and size of the x-ray source designed in Phase I are compatible with clinical use. In Phase II, proof-of-principle experiments will be performed to verify the operating capabilities and constraints of the proposed x-ray source. A prototype electron accelerator and target assembly will be constructed and used to conduct dual-energy subtraction imaging experiments on phantoms. Two detector configurations will be evaluated. An upgraded accelerator and target design capable of providing the high photon fluxes required for the clinical implementation of this technique will be developed.