NEUTRON CAPTURE SYNOVECTOMY FOR RHEUMATOID ARTHRITIS

中子捕获滑膜切除术治疗类风湿性关节炎

• 批准号: 2421655
• 负责人: RUTH E SHEFER
• 金额: $ 40.77万
• 依托单位: NEWTON SCIENTIFIC, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2421655
• 关键词: boron; fingers; immunopathology therapy; inflammation; joints; knee; lithium; neutron radiation; orthopedics; particle accelerators; phantom model; radiation dosage; radiation therapy; radionuclides; rheumatoid arthritis; synovial membrane

The goal of this program is to determine the feasibility of synovectomy using the 10B(n,alpha)7 Li nuclear reaction with an external neutron beam for the treatment of rheumatoid arthritis (RA). This therapy has two potential advantages over surgical or radiation synovectomy with beta- emitters for RA: it is non-invasive and it does not require the administration of radioactive materials to the patient. Recent experiments have shown that very high boron concentrations can be achieved in active human synovium in vitro. However, the required neutron beam characteristics for therapy are presently unknown. In Phase I, Monte Carlo simulation techniques will be used to determine the required boron distribution and neutron beam parameters for successful therapy of the human synovial joints most commonly involved in RA. An optimized accelerator-based neutron beam design which minimizes radiation dose to non-target tissues in neutron capture synovectomy will then be developed. This work will lead to the construction of a neutron therapy beamline in Phase II and will provide the quantitative basis for future in vivo studies of synovial tissue ablation using the 10B(n,alpha) reaction. PROPOSED COMMERCIAL APPLICATION: Rheumatoid arthritis affects approximately 1% of the population of the United States. The proposed synovectomy procedure could be performed on an outpatient basis at about one-tenth the cost of a surgical synovectomy. If this technique is shown to be safe and effective, a large market for therapy beams will exist.

这个程序的目的是确定滑膜切除术的可行性