PEPTIDE SYNTHESIZER WITH PREPARATIVE AND ANALYTICAL HPLC

需要资金购买必要的设备， 构成一个功能齐全的自动化肽合成设施， 肯塔基州大学。 该设施将纳入和 完成我们的高分子结构分析核心实验室。 这 实验室已经配备了目前最好的设备 用于蛋白质/肽测序和分析以及用于寡核苷酸 合成和测序。 目前的设备包括ABI气相 蛋白质测序仪、Beckman Model 6300氨基酸分析仪和ABI 自动寡核苷酸合成仪。 只有这些设施 在肯塔基州和我们的200英里半径内提供 大学 因此，它们对于许多研究至关重要 NIH资助的研究人员在这个校园，上面列出的共同研究者 他们的研究计划在《圣经》的叙述部分中阐述， 应用程序. 这些独特的设施也将作为一个研究 资源的其他成员的科学界在我们的地理 在一个优先的，收费使用的基础上，区域。

Funds are requested to purchase the items of equipment necessary to constitute a fully functional automated peptide synthesis facility at the University of Kentucky. This facility will be incorporated into and complete our Macromolecular Structure Analysis Core Laboratory. This laboratory is already equipped with the best currently available equipment for protein/peptide sequencing and analysis and for oligonucleotide synthesis and sequencing. Current equipment includes an ABI gas phase protein sequencer, a Beckman Model 6300 amino acid analyzer and an ABI automatic oligonucleotide synthesizer. These facilities are the only such available within the State of Kentucky and within a 200 mile radius of our University. Thus, they are essential for the studies of a number of NIH-funded investigators on this campus, listed above as co-investigators and whose research programs are set forth in the narrative portions of the application. These unique facilities will also serve as a research resource for other members of the scientific community in our geographic region on a prioritized, fee-for-use basis.