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WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISON

WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISON
适用于威斯康星大学麦迪逊分校的大口径 9.4 特斯拉 NMR 光谱仪
批准号:
3519420
负责人:
JOHN LUTE MARKLEY
金额:
$30.0万
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-04-01 至 1987-03-31

项目摘要

项目成果

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中文摘要
翻译
部分资金用于购买高分辨率,高视场,
英文摘要
Partial funds are requested to purchase a high-resolution, high-field, (9.4\T), wide-bore, multinuclear magnetic resonance spectrometer for the Biochemical Magnetic Resonance Facility to be located in the first floor of the new wing of the Biochemistry Building, Department of Biochemistry, University of Wisconsin-Madison. The instrumentation has been chosen to optimize the collection and analysis of one- and two-dimensional NMR data sets and for carrying out biomedical NMR experiments requiring the ultimate in spectrometer sensitivity. The instrument is to be used about 10% for core research by the NMR facility to develop new approaches to hetero-nuclear two-dimensional NMR spectroscopy of macromolecules, isotopic labeling of biomolecules for NMR analysis, and multinuclear magnetic resonance studies of viruses, living cells, and intact tissues. About 80% of the spectrometer time will be devoted to supporting the research efforts of ten major investigators who have NIH peer-reviewed research support in the following areas: structure and function of proteins, nucleic acids, and natural products; active sites and mechanisms of enzymes; modes of action of drugs; and physiological levels of metabolites in living cells and organisms. The remaining 10% of the spectrometer time will be devoted to training and routine maintenance and repairs. Day-to-day administration of the instrumentation will be handled by the staff of the NMR facility with supervision of a Local Steering Committee including representatives from major user groups. The overall performance of the entire facility will be reviewed regularly by an Advisory Committee of experts in the field of biological NMR.
期刊论文(18)
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会议论文
Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp.
马杜拉他汀 D1 和 D2,从马杜拉放线菌中分离出的含有恶唑啉的铁载体。
DOI: 10.1021/acs.orglett.9b02159
发表时间: 2019
期刊: Organic letters
影响因子: 5.2
作者: [Yan,Jia-Xuan, Chevrette,MarcG, Braun,DougR, Harper,MaryKay, Currie,CameronR, Bugni,TimS]
通讯作者: Bugni,TimS
DOI: 10.1073/pnas.1512088112
发表时间: 2015-11-24
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Au, Hilda H., Cornilescu, Gabriel, Jan, Eric]
通讯作者: Jan, Eric
An NMR study of cellular phosphates and membrane transport in renal proximal tubules.
肾近曲小管细胞磷酸盐和膜转运的核磁共振研究。
DOI: 10.1152/ajprenal.1995.268.3.f375
发表时间: 1995
期刊: The American journal of physiology.
影响因子: --
作者: [Chobanian,MC, Anderson,ME, Brazy,PC]
通讯作者: Brazy,PC
DOI: 10.1007/s10858-015-9933-8
发表时间: 2015-08
期刊: Journal of biomolecular NMR
影响因子: 2.7
作者: [Dashti H, Lee W, Tonelli M, Cornilescu CC, Cornilescu G, Assadi-Porter FM, Westler WM, Eghbalnia HR, Markley JL]
通讯作者: Markley JL
11
    Biogenesis of human mitochondrial iron-sulfur proteins
    • 批准号:
      10001537
    • 项目类别:
    • 资助金额:
      $35.94万
    • 财政年份:
      2019
    • 负责人:
      JOHN LUTE MARKLEY
    • 依托单位:
    The BMRB as an evolving resource for biomolecular structure-function research
    • 批准号:
      9462715
    • 项目类别:
    • 资助金额:
      $66.22万
    • 财政年份:
      2014
    • 负责人:
      JOHN LUTE MARKLEY
    • 依托单位:
    The BMRB as an evolving resource for biomolecular structure-function research
    • 批准号:
      8615052
    • 项目类别:
    • 资助金额:
      $16.12万
    • 财政年份:
      2014
    • 负责人:
      JOHN LUTE MARKLEY
    • 依托单位:
    The BMRB as an evolving resource for biomolecular structure-function research
    • 批准号:
      9253407
    • 项目类别:
    • 资助金额:
      $66.22万
    • 财政年份:
      2014
    • 负责人:
      JOHN LUTE MARKLEY
    • 依托单位:
    海外基金