Nucleophilic Alkaline Earth Boryls: From Conception and Theory to Application

亲核碱土硼基化合物:从概念、理论到应用

基本信息

  • 批准号:
    EP/R020752/1
  • 负责人:
  • 金额:
    $ 162.74万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2018
  • 资助国家:
    英国
  • 起止时间:
    2018 至 无数据
  • 项目状态:
    已结题

项目摘要

Some of the greatest benefits to human health and well-being have been provided by modern methods of chemical synthesis. Boron compounds provide some of the most widely used reagents in chemistry and are employed in myriad syntheses of pharmaceutical and other high value molecules (e.g. with uses in electronic materials and chemical sensing). Organoborane, boronate ester and boronic acid derivatives, thus, provide some of the most practically useful intermediates in synthetic and medicinal chemistry, to the extent that the application of boron in organic synthesis has been recognised by the award of two Nobel prizes (Brown in 1979 and Suzuki in 2010). Despite these advances, almost all of these compounds are synthesised from starting materials in which boron acts as an electron acceptor (electrophile). This is a natural consequence of boron's position at the top of group 13 in the periodic table and presents a severe limitation to the types and variety of boron compounds that can be made. In this project we will build on our recent discovery (Nature Commun. 2017, 8, 15022) that derivatives in which boron is bonded to a less electronegative group 2 element, magnesium, are easily generated by activation of the B-B bonds of commercially available diboranes. In contrast to the vast majority of available boron reagents, the boron in these compounds reacts as a potent electron donor (nucleophile), providing the potential to allow the synthesis of a wide variety of new boron-containing molecules. In this project, we will apply a multifaceted inorganic/organic synthetic and computational approach to devise, understand and apply a wide array of new and highly reactive boron derivatives of the group 2 metals, primarily magnesium and calcium. The attractiveness of these latter elements is underscored by their negligible toxicity, high natural abundance and resultant low cost. Furthermore, the boron nucleophiles developed in this project will be used in the synthesis of a plethora of unprecedented and previously inaccessible organic and inorganic boron-containing compounds. Our ultimate objective is to ensure that these reagents are available from commercial chemical suppliers and nothing short of establishing previously inaccessible boron nucleophiles as off-the-shelf reagents in the synthetic chemist's larder.
现代化学合成方法为人类健康和福祉带来了一些最大的好处。硼化合物是化学中使用最广泛的试剂之一,并被用于无数药物和其他高价值分子的合成(例如用于电子材料和化学传感)。因此,有机硼烷、硼酸酯和硼酸衍生物在合成化学和药物化学中提供了一些最实用的中间体,以至于硼在有机合成中的应用获得了两项诺贝尔奖(1979年布朗奖和2010年铃木奖)。尽管取得了这些进展,但几乎所有这些化合物都是由硼作为电子受体(亲电试剂)的原料合成的。这是硼在元素周期表中位于第13族顶部的自然结果,并且对可以制造的硼化合物的类型和种类提出了严重的限制。在这个项目中,我们将以我们最近的发现(Nature common . 2017,8,15022)为基础,即硼与电负性较低的第2族元素镁结合的衍生物,很容易通过激活商业上可用的二硼烷的B-B键产生。与绝大多数可用的硼试剂相比,这些化合物中的硼作为一个强有力的电子供体(亲核试剂)反应,提供了允许合成各种新的含硼分子的潜力。在这个项目中,我们将采用多方面的无机/有机合成和计算方法来设计、理解和应用一系列新的和高活性的2族金属硼衍生物,主要是镁和钙。这些后一种元素的吸引力在于它们的毒性可忽略不计,天然丰度高,因而成本低。此外,在这个项目中开发的亲核硼试剂将用于合成大量前所未有的和以前难以获得的有机和无机含硼化合物。我们的最终目标是确保这些试剂可以从商业化学品供应商那里获得,并且在合成化学家的储藏室中建立以前无法获得的亲核硼试剂作为现成的试剂。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Carbon-Carbon Bond Forming Reactions Promoted by Aluminyl and Alumoxane Anions: Introducing the Ethenetetraolate Ligand
铝基和铝氧烷阴离子促进的碳-碳键形成反应:引入乙烯四醇盐配体
  • DOI:
    10.1002/ange.202005301
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anker M
  • 通讯作者:
    Anker M
Potassium Aluminyl Promoted Carbonylation of Ethene
铝基钾促进乙烯羰基化
  • DOI:
    10.1002/ange.202117396
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Evans M
  • 通讯作者:
    Evans M
Potassium Aluminyl Promoted Carbonylation of Ethene.
  • DOI:
    10.1002/anie.202117396
  • 发表时间:
    2022-04-11
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Evans, Matthew J.;Neale, Samuel E.;Anker, Mathew D.;McMullin, Claire L.;Coles, Martyn P.
  • 通讯作者:
    Coles, Martyn P.
Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines.
  • DOI:
    10.1021/jacs.1c07401
  • 发表时间:
    2021-10-06
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Askey HE;Grayson JD;Tibbetts JD;Turner-Dore JC;Holmes JM;Kociok-Kohn G;Wrigley GL;Cresswell AJ
  • 通讯作者:
    Cresswell AJ
Decarboxylative, Radical C-C Bond Formation with Alkyl or Aryl Carboxylic Acids: Recent Advances
烷基或芳基羧酸脱羧、自由基 C-C 键形成:最新进展
  • DOI:
    10.1055/a-2081-1830
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Cresswell A
  • 通讯作者:
    Cresswell A
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Michael Hill其他文献

Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno-associated virus gene therapy manufacturing.
基于计算流体动力学的固定床生物反应器数字孪生验证了重组腺相关病毒基因治疗制造的缩放原理。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Michael Hill;Colten White;Shaoying Wang;John A Thomas;Brian DeVincentis;Nripen Singh
  • 通讯作者:
    Nripen Singh
Discretion and Welfare Rights in a British Context
英国背景下的自由裁量权和福利权
Taiwan: what kind of social policy regime?
台湾:什么样的社会政策制度?
Assessing needs for interdisciplinarity in agriculture, nutrition, and health education
评估农业、营养和健康教育跨学科的需求
  • DOI:
    10.1016/j.gfs.2023.100691
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Reshma P. Roshania;J. Yates;Lauren J. McIntyre;T. Chancellor;E. Fivian;Michael Hill;R. Isoto;P. Marinda;S. Narayanan;Louise Whatford;F. Zotor;S. Khandelwal
  • 通讯作者:
    S. Khandelwal
A common emNFKB1/em variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
通过英国生物银行中的抗体分析检测到的一种常见的 emNFKB1/em 变体预测了感染和过敏的风险
  • DOI:
    10.1016/j.ajhg.2023.12.013
  • 发表时间:
    2024-02-01
  • 期刊:
  • 影响因子:
    8.100
  • 作者:
    Amanda Y. Chong;Nicole Brenner;Andres Jimenez-Kaufmann;Adrian Cortes;Michael Hill;Thomas J. Littlejohns;James J. Gilchrist;Benjamin P. Fairfax;Julian C. Knight;Flavia Hodel;Jacques Fellay;Gil McVean;Andres Moreno-Estrada;Tim Waterboer;Adrian V.S. Hill;Alexander J. Mentzer
  • 通讯作者:
    Alexander J. Mentzer

Michael Hill的其他文献

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{{ truncateString('Michael Hill', 18)}}的其他基金

Conference: Motivic and non-commutative aspects of enumerative geometry, Homotopy theory, K-theory, and trace methods
会议:计数几何的本构和非交换方面、同伦理论、K 理论和迹方法
  • 批准号:
    2328867
  • 财政年份:
    2023
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Standard Grant
Molecular s-block Assemblies for Redox-active Bond Activation and Catalysis: Repurposing the s-block as 3d-elements
用于氧化还原活性键活化和催化的分子 s 块组装:将 s 块重新用作 3d 元素
  • 批准号:
    EP/X01181X/1
  • 财政年份:
    2023
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Research Grant
FRG: Collaborative Research: Trace Methods and Applications for Cut-and-Paste K-Theory
FRG:协作研究:剪切粘贴 K 理论的追踪方法和应用
  • 批准号:
    2052702
  • 财政年份:
    2021
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Standard Grant
Equivariant Approaches to Chromatic Homotopy
色同伦的等变方法
  • 批准号:
    2105019
  • 财政年份:
    2021
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Continuing Grant
Computations in Stable and Unstable Equivariant Chromatic Homotopy
稳定和不稳定等变色同伦的计算
  • 批准号:
    1811189
  • 财政年份:
    2018
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Continuing Grant
Augmentation of Alkaline Earth Reactivity: An FLP Analogy
碱土反应性的增强:FLP 类比
  • 批准号:
    EP/N014456/1
  • 财政年份:
    2016
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Research Grant
Equivariant Derived Algebraic Geometry
等变导出的代数几何
  • 批准号:
    1509652
  • 财政年份:
    2015
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Continuing Grant
Computations in Equivariant Homotopy and Algebraic K-Theory
等变同伦和代数 K 理论中的计算
  • 批准号:
    1207774
  • 财政年份:
    2012
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Standard Grant
Scalable, low-cost organic photovoltaic devices
可扩展、低成本的有机光伏器件
  • 批准号:
    EP/J50001X/1
  • 财政年份:
    2011
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Research Grant
Group 2: Elements of 21st Century Catalysis
第 2 组:21 世纪催化要素
  • 批准号:
    EP/I014519/1
  • 财政年份:
    2011
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Research Grant

相似海外基金

Reactivity Enhanced Low-Valent Alkaline Earth Metal Compounds
反应活性增强的低价碱土金属化合物
  • 批准号:
    DP240101097
  • 财政年份:
    2024
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Discovery Projects
Vitrification of intermediate level wastes using alkaline earth aluminosilicate glasses
使用碱土铝硅酸盐玻璃对中放废物进行玻璃化
  • 批准号:
    2897514
  • 财政年份:
    2023
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    $ 162.74万
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    Studentship
SubVAR - Sub-Valent Alkaline Earth Reagents
SubVAR - 亚价碱土试剂
  • 批准号:
    EP/W00691X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 162.74万
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    Research Grant
Intermetallic and Extraordinary Bonds of Beryllium and the Alkaline Earth Metals
铍和碱土金属的金属间键和非常键
  • 批准号:
    2055579
  • 财政年份:
    2021
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Continuing Grant
Distributed Quantum Computing and Metrology with Alkaline Earth Atom Arrays
碱土原子阵列的分布式量子计算和计量
  • 批准号:
    2112663
  • 财政年份:
    2021
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Continuing Grant
Synthesis, Characterisation and Reactivity of Unusual Alkaline Earth Metal Complexes
异常碱土金属配合物的合成、表征及反应活性
  • 批准号:
    2590258
  • 财政年份:
    2021
  • 资助金额:
    $ 162.74万
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    Studentship
Development of Alkaline Earth Salts having Highly Enhanced Radiophotoluminescence Properties
开发具有高度增强的放射光致发光性能的碱土盐
  • 批准号:
    20K15207
  • 财政年份:
    2020
  • 资助金额:
    $ 162.74万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
New Landscapes in Alkaline Earth and Lanthanide Chemistry
碱土和稀土化学的新景观
  • 批准号:
    2437835
  • 财政年份:
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  • 资助金额:
    $ 162.74万
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Niobium, zirconium, titanium, and rare earth elements in alkaline silica-undersatured magmas: experimental determination of solubility, complexation and phase relations and implications for the formation of magmatic Nb-Zr-REE deposits
碱性二氧化硅-欠饱和岩浆中的铌、锆、钛和稀土元素:溶解度、络合和相关系的实验测定以及对岩浆铌-锆-稀土矿床形成的影响
  • 批准号:
    441268636
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    2020
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    $ 162.74万
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    Priority Programmes
SBIR Phase II: Spatially Modulated Light For Trapping And Addressing Of Alkaline-Earth Neutral Atom Qubits
SBIR 第二阶段:用于捕获和寻址碱土中性原子量子位的空间调制光
  • 批准号:
    1951188
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    2020
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