AGING AND HUMAN ENDOCRINE REGULATION

衰老与人体内分泌调节

• 批准号: 3789735
• 负责人: S MITCHELL HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789735
• 关键词: aging; arginine; blood chemistry; circadian rhythms; dietary aminoacid; dietary supplements; dosage; drug administration rate /duration; drug administration routes; drug delivery systems; endocrine pharmacology; growth hormone releasing hormone; hormone regulation /control mechanism; human old age (65+); human subject; insulinlike growth factor; lysine; male; nutrition related tag; oral administration; secretion; somatotropin; young adult human (21-34)

A study of 24 hr pulsatile GH secretion, acute GH response to iv GHRH, and plasma IGF-I measurements in older men, before and after two weeks of either twice daily sc GHRH injections or constant sc GHRH infusions by portable pump, each repeated at 2 different doses, has been completed. We demonstrated that pulsatile GH secretion and serum IGF-I levels were low in older men, and increased into the range seen in normal young men after treatment with 2 mg of GHRH by injection and either dose by infusion. Diurnal pulsatile secretory variation appeared more physiological with GHRH injections than during infusions, in that infusion tended to raise the interpeak (basal) GH levels and to diminish amplitude of nocturnal GH secretory peaks. GHRH treatment also resulted in apparent phosphate retention, suggesting an increase in protein synthesis. There were no adverse effects. A study of 2 weeks or orally administered 50:50 arginine/lysine mixture vs. placebo on GH and IGF-I secretion in older men has shown no effects on spontaneous GH secretory pattern, GH responses to GHRH, and serum IGF-I levels, suggesting that oral amino acids may not be a useful GH-stimulating intervention in the elderly.

24小时脉冲式生长激素分泌、静脉注射生长激素释放激素的急性生长激素反应和 血浆IGF-I测量老年男性，之前和之后两个星期， 每日两次皮下GHRH注射或通过皮下GHRH持续输注 便携式泵，每种重复2个不同的剂量，已经完成。 我们 表明，脉冲GH分泌和血清IGF-I水平低， 老年男性，并增加到正常年轻男性的范围后， 注射2 mg GHRH和输注任一剂量治疗。 GHRH的昼夜脉冲式分泌变化更接近生理变化 注射比在输液期间，在输液往往会提高 峰间（基础）GH水平和降低夜间GH的幅度 分泌高峰。 GHRH处理也导致表观磷酸盐 保留，表明蛋白质合成增加。 没有 不良影响 2周或口服50：50的研究 精氨酸/赖氨酸混合物与安慰剂对老年男性GH和IGF-I分泌的影响 对自发GH分泌模式、GH对 GHRH和血清IGF-I水平，表明口服氨基酸可能不是 对老年人有益的GH刺激干预。