HORMONES, HORMONE RECEPTORS, AND AGING - III AGING AND HUMAN ENDOCRINE REGULATION

激素、激素受体和衰老 - III 衰老和人体内分泌调节

• 批准号: 3823122
• 负责人: S MITCHELL HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823122
• 关键词: adrenocorticotropic hormone; aging; blood chemistry; estrogens; follicle stimulating hormone; gonadotropin releasing factor; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); human subject; human tissue; immunochemistry; longitudinal human study; luteinizing hormone; peptide hormone metabolism; pituitary gonadal axis; prolactin; psychobiology; radioimmunoassay; somatotropin; steroid hormone; testosterone; thyroid hormones; thyrotropin; tissue /cell culture

Our clinical studies gather data on pituitary secretory function as it relates to gonadal, adrenal, thyroid, prolactin, and growth hormone regulation in normal aging humans. Our most recent findings were that growth hormone (GH) and somatomedin-C (Sm-C) responsiveness to GRF (growth hormone releasing factor) and ACTH and cortisol responsiveness to CRF (corticotropin releasing factor) are unaltered with age, whereas CRF mediated DHEA secretion is greatly reduced, suggesting independent regulation of cortisol and DHEA secretion. Basal and TRH stimulated Prl secretion are increased in older vs. younger men. We have recently measured testosterone, testosterone binding, and gonadotropins in a large group of men of various ages with and without chronic illness and have shown that there is modest, but significant, decrease in both total and free plasma testosterone (T) with age, accompanied by increased FSH, but not LH. The effects of illness were a profound (compared with effects of aging) lowering of free (but not total) T in patients with benign disease, and lowering of both free and total T in patients with cancer. Continuing studies address the interrelationships among circulating estrogens and androgens, incidence of cardiovascular disease, and known cardiovascular risk factors, such as lipoprotein profile, obesity, and body fat distribution. We plan studies of the temporal regulation and feedback sensitivity of the ACTH-adrenal axis in the coming year.

我们的临床研究收集了垂体分泌功能的数据， 与性腺、肾上腺、甲状腺、催乳素和生长激素有关 调节正常衰老的人类。 我们最近的发现是， 生长激素（GH）和生长调节素-C（Sm-C）对GRF（生长 激素释放因子）和促肾上腺皮质激素和皮质醇对CRF反应性 （促肾上腺皮质激素释放因子）不随年龄变化，而CRF 介导的DHEA分泌大大减少，这表明独立 调节皮质醇和脱氢表雄酮分泌。 基础和TRH刺激的Prl 老年男性与年轻男性相比分泌增加。 我们最近 测量睾酮，睾酮结合，和促性腺激素在一个大的 一组不同年龄的男性，有或没有慢性疾病， 显示，在这两个领域， 血浆游离睾酮（T）随着年龄的增长，伴随FSH的增加，但 不是LH。 疾病的影响是深远的（与疾病的影响相比， 衰老）良性疾病患者的游离（但不是总）T降低， 降低癌症患者的游离T和总T。 继续 研究指出了循环雌激素和 雄激素、心血管疾病的发病率和已知的心血管疾病 风险因素，如脂蛋白谱、肥胖和体脂 分布 我们计划研究的时间调节和反馈 促肾上腺皮质激素-肾上腺轴的敏感性在未来一年。