HORMONES AND AGING--PITUITARY, AND HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS

对大鼠脑下垂体分泌细胞进行了体外研究，以比较其与正常对照组的差异。 老年和幼年动物的生理学。产促甲状腺激素和催乳素 促黄体生成素和卵泡刺激素及其亚基对TRH的反应 对LRH进行测量以研究其功能的改变 垂体腺分泌细胞。老年人垂体腺细胞功能紊乱 体外实验已经被发现。去势增加LRH的反应性 老年大鼠和青年大鼠的促性腺激素水平相同。前处理 LRH大鼠部分恢复黄体生成素分泌功能 这表明，至少在一定程度上，下丘脑缺陷是 对观察到的与年龄相关的黄体生成素分泌减少负责。

Secretory cells from rat pituitaries are studied in vitro to compare their physiology in old and young animals. Production of TSH and prolactin in response to TRH and production of LH and FSH and their subunits in response to LRH are being measured in order to investigate altered function of pituitary secretory cells. Deranged function of aged pituitary cells in vitro has been found. Castration increases LRH responsiveness of gonadotrophs of aged and young rats to the same extent. Pretreatment of rats with LRH has partially restored LH secretory function of cells from old animals, suggesting that hypothalamic deficiency is, at least in part, responsible for the observed age-related reduction in LH secretion.