AGING AND HUMAN ENDOCRINE REGULATION
AGING AND HUMAN ENDOCRINE REGULATION
批准号:
3767746
负责人:
S MITCHELL HARMAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
aging blood chemistry body physical characteristic bone metabolism circadian rhythms drug administration routes endocrine pharmacology glucose tolerance test growth hormone releasing hormone high density lipoproteins high energy compound hormone regulation /control mechanism human old age (65+) human subject insulinlike growth factor lipids muscle strength nutrition related tag secretion sleep somatotropin
中文摘要
我们研究了12名65岁的健康男性的夜间睡眠和夜间活动
英文摘要
We studied 12 healthy men >65 years old overnight for sleep and nocturnal
GH secretory profiles, as well as for glucose tolerance,IGF-I,T,
osteocalcin, lipid profiles, and bone biochemistries (urine pyridinoline
cross-links, and calcium), body composition, muscle strength and
utilization of high energy phosphate by NMR, all before and at the end of
a regimen of GHRH 1-29 self-injected sc once nightly for 6 weeks. There
was a significant increase in GH secretion after GHRH injections, in mean
serum IGF-I levels, and in muscle strength and significant decreases in
area under glucose tolerance curves and in LDL cholesterol, but no changes
in triglycerides or HDL cholesterol and no apparent effect of treatment on
body mass index, other anthropometric measures or measures of bone
metabolism. A study of the effects of 6 months of treatment of 160 men and
women >65 years with rhGH, sex steroid, both, or neither on multiple
relevant clinical and physiologic end-points has been initiated and is
ongoing.
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会议论文
HORMONES, HORMONE AND AGING
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批准号:3808839
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY, AND HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3823126
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3767750
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3808842
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS AND AGING.III--AGING AND HUMAN ENDOCRINE REGULATION
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批准号:3802181
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
AGING AND HUMAN ENDOCRINE REGULATION
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批准号:3789735
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3745425
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS, & AGING - III. AGING & HUMAN ENDOCRINE REGULATION
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批准号:3821404
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS, AND AGING - III AGING AND HUMAN ENDOCRINE REGULATION
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批准号:4687863
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3802185
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
EFFECTS OF AGE ON REGULATION OF HPA AXIS IN MEN
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批准号:3888150
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS, AND AGING - III AGING AND HUMAN ENDOCRINE REGULATION
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批准号:3823122
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY, AND HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3817552
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS, AND AGING--AGING AND HUMAN ENDOCRINE REGULATION
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批准号:5200260
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:3789739
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--PITUITARY, AND HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:4687867
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES, HORMONE RECEPTORS, AND AGING. AGING AND HUMAN ENDOCRINE REGULATION
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批准号:3745421
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
HORMONES AND AGING--HYPOTHALAMIC-PITUITARY FUNCTION IN EXPERIMENTAL ANIMALS
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批准号:5200264
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S MITCHELL HARMAN
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依托单位:
海外基金