HORMONES, HORMONE RECEPTORS, & AGING - III. AGING & HUMAN ENDOCRINE REGULATION

激素、激素受体、

• 批准号: 3821404
• 负责人: S MITCHELL HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821404
• 关键词: aging; blood chemistry; bone metabolism; estrogens; follicle stimulating hormone; gonadotropins; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); human subject; human tissue; immunochemistry; longitudinal human study; lung neoplasms; luteinizing hormone; menopause; pituitary gonadal axis; radioimmunoassay; testosterone

In the past year, our clinical studies have been oriented to (1) discriminating between the effects of primary aging vs. age- associated illness on pituitary gonadal function in men and (2) examining the interrelationships between circulating sex steroid hormone levels and various risk factors for coronary artery disease (CAD). We have measured testosterone (T), T binding, and gonadotropins in a large group of healthy men and men with benign or malignant lung disease. We found that: (a) there is an increased prevalence of both pituitary gonadotropic and testicular dysfunction in men with lung cancer and, to a lesser extent benign lung disease and (b) the effects of illness are independent of and quantitatively greater than those of aging. We also measured plasma levels of T and estradiol (E2) in 53 men prior to their development of CAD and in 136 controls who remained without CAD. We found no significant association between levels of T, E2, or the ratio T to E2 and subsequent development of CAD. We plan to initiate or continue investigations of (a) the effects of parenteral estrogen replacement on various hormonal parameters related to bone metabolism in healthy postmenopausal women of different ages, (b) the interrelationships between sex hormones and certain CAD risk factors in healthy cycling and postmenopausal women, and (c) the effects of aging on the pituitary adrenal hormone dynamics in men and women.

在过去的一年里，我们的临床研究主要集中在（1） 区分初级老化与年龄的影响， 男性垂体性腺功能相关疾病和（2） 研究循环性类固醇和 激素水平和各种冠状动脉危险因素 疾病（CAD）。 我们测量了睾酮（T），T结合， 促性腺激素在一大群健康男性和男性 良性或恶性肺部疾病。 我们发现：（a）有一个 垂体促性腺激素和睾丸激素 男性肺癌患者的功能障碍， 肺疾病和（B）疾病的影响独立于和 数量上大于老化。 我们还测量 血浆T和雌二醇（E2）水平在53名男子之前， CAD的发展和136名对照谁仍然没有 CAD. 我们没有发现T水平之间的显著关联， E2，或T与E2的比值以及CAD的后续发展。 我们 计划启动或继续调查（a） 胃肠外雌激素替代对各种激素参数的影响 与健康绝经后妇女的骨代谢相关 不同年龄，（B）性激素之间的相互关系 和健康自行车运动中的某些CAD风险因素， 绝经后妇女，和（c）老化对 男性和女性的垂体肾上腺激素动力学。