HORMONES AND AGING--PITUITARY-HYPOTHALAMIC FUNCTION IN EXPERIMENTAL ANIMALS

激素与衰老--实验动物的垂体-下丘脑功能

• 批准号: 3745425
• 负责人: S MITCHELL HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745425
• 关键词: aging; biological signal transduction; genetic transcription; glycolysis; growth factor receptors; hormone regulation /control mechanism; hypothalamic pituitary axis; insulinlike growth factor; laboratory mouse; messenger RNA; molecular cloning; nuclear runoff assay; pituitary gland; polymerase chain reaction; somatotropin; testosterone; translation factor

We are using specific antibodies to distinguish which subspecies of inhibitory GTP binding proteins are altered during aging. There has been a hiatus in the molecular aspect of this work due to the departure of the principal individual engaged in this project (Dr. Lu). As of January 1994 a new investigator (Dr. P. Ponsalle) has been brought in as an IRTA fellow to reorganize and pursue this work.

我们用特异性抗体来区分 抑制性GTP结合蛋白在衰老过程中发生改变。 一直 在这项工作的分子方面，由于 参与该项目的主要人员（卢博士）。 截至 1994年1月，一名新的调查员（P. Ponsalle博士）被请来， 一个IRTA研究员来重组和继续这项工作。