HORMONES, HORMONE RECEPTORS, AND AGING - III AGING AND HUMAN ENDOCRINE REGULATION

激素、激素受体和衰老 - III 衰老和人体内分泌调节

• 批准号: 4687863
• 负责人: S MITCHELL HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687863
• 关键词: aging; blood chemistry; estrogens; follicle stimulating hormone; gonadotropin releasing factor; hormone regulation /control mechanism; human middle age (35-64); human old age (65+); human subject; human tissue; immunochemistry; longitudinal human study; luteinizing hormone; peptide hormone metabolism; pituitary gonadal axis; prolactin; psychophysiology; radioimmunoassay; somatotropin; steroid hormone; testosterone; thyroid hormones; thyrotropin; tissue /cell culture

These studies gather data on pituitary function as it relates to gonadal, thyroid, adrenal, and growth hormone regulation in normal aging men from the Baltimore Longitudinal Study on Aging (BLSA). Recent results have shown that healthy men have no apparent change in growth hormone secretion compared with the decrements of secretory capacity reported for less well selected populations, but subtle alterations in diurnal secretory pattern for ACTH and cortisol, with a decrease in AM/PM cortisol ratio and a trend toward increased pituitary ACTH response to corticotropin releasing factor (CRF). The DHEA secretory response for ACTH is greatly decreased with age, in contrast to the results for cortisol, suggesting independent regulation of cortisol and DHEA secretion.

这些研究收集了垂体功能的数据，因为它与性腺， 甲状腺，肾上腺和生长激素调节正常老年男性， 巴尔的摩老龄化纵向研究（BLSA）。 最近的结果 显示健康男性生长激素分泌没有明显变化 与报告的分泌能力下降相比， 选择种群，但昼夜分泌模式的细微变化 促肾上腺皮质激素和皮质醇，上午/下午皮质醇比率下降， 增加垂体ACTH对促肾上腺皮质激素释放因子的反应 （通用报告格式）。 DHEA对ACTH的分泌反应随着年龄的增长而大大降低， 与皮质醇的结果相反，表明独立调节 皮质醇和脱氢表雄酮的分泌。