RELATIONSHIP OF PSYCHOBIOLOGY TO PSYCHOPATHOLOGY IN ALCOHOLICS

酗酒者心理生物学与心理病理学的关系

• 批准号: 3789530
• 负责人: D GEORGE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789530
• 关键词: alcoholism /alcohol abuse; anxiety; blood chemistry; cerebrospinal fluid; depression; human subject; imipramine; isoproterenol; lactates; norepinephrine; panic disorder; psychobiology; urinalysis

Alcoholism and affective disorders frequently occur in the same individuals and in members of the same family. This association may represent the co-existence of two common disease entities due to chance or due to (a) alcoholism resulting from self-medication of an underlying affective disorder, or (b) depression resulting from consequences of alcohol abuse. Studies have shown that alcohol may acutely improve the sense of affective well-being, but with continued intoxication this improvement may be reversed. Also, during chronic intoxication, alcoholics not only become increasingly depressed but also more anxious. In this protocol, certain biochemical aspects of depression and anxiety are characterized as they are manifested in alcoholic patients. Cerebrospinal fluid and plasma are analyzed for norepinephrine (lying and standing), urine for catecholamine metabolites and pharmacological challenge paradigms using lactate, isoproterenol and chlorimipramine are employed. Results indicate that alcoholics with panic disorder have a number of distinguishing biological characteristics: (1) alcoholics with panic have a reduced response to lactate administration compared to panic patients without alcoholism; (2) higher CSF B-endorphin charateristics compared to controls and (3) a heightened affective response to chlorimipramine compared with alcoholics and controls.

酒精中毒和情感障碍经常发生在同一个 个人和同一家庭的成员。 该关联可以 代表由于偶然或 由于（a）潜在的自我药物治疗引起的酒精中毒 情感性精神障碍，或（B）由以下后果导致的抑郁症 酗酒 研究表明，酒精可以大大改善 情感幸福感，但随着持续的陶醉， 改善可能会逆转。 另外，在慢性中毒期间， 酗酒者不仅变得越来越抑郁，而且越来越焦虑。 在这个方案中，抑郁和焦虑的某些生化方面 表现为酗酒患者的症状。 分析脑脊液和血浆中的去甲肾上腺素（躺下和躺下）。 站立），尿中的儿茶酚胺代谢产物和药理学 使用乳酸盐、异丙肾上腺素和氯丙咪嗪的激发范例是 就业。 结果表明，患有惊恐障碍的酗酒者有许多 区别生物学特征：（1）具有惊恐的酗酒者， 与恐慌患者相比，对乳酸盐给药的反应降低 无酒精中毒;（2）CSF B-内啡肽特征高于 对照组和（3）对氯丙咪嗪的情感反应增强 与酗酒者和对照组相比。