PSYCHOBIOLOGY OF ALCOHOLISM IN WOMEN

女性酗酒的心理生物学

• 批准号: 6160377
• 负责人: D GEORGE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160377
• 关键词: alcoholism /alcohol abuse; clinical research; female; gender difference; human subject; male; piperazines; psychobiology; psychopharmacology

Studies suggest that the pathophysiology of alcoholism may differ significantly between men and women. To explore this possibility, we have employed several pharmacological challenge paradigms to compare the behavioral and endocrine responses between male and female alcoholics. Preliminary analysis of our results show that the m- chlorophenylpiperazine (m-CPP) gives rise to a variety of behavioral responses in women alcoholics ranging from severe anxiety to euphoria. This corresponds to the responses obtained from male alcoholics demonstrated in a previous study. In contrast, very few of the women experienced an m-CPP induced "desire to drink" response which was demonstrated to occur in approximately 40 percent of the Type II (early onset) male alcoholics.

研究表明，酒精中毒的病理生理学可能不同， 男性和女性之间的差异很大。 为了探索这种可能性，我们 采用了几种药理学挑战范式来比较 男性和女性酗酒者之间的行为和内分泌反应。 初步分析结果表明，m- 氯苯基哌嗪（m-CPP）引起多种行为 女性酗酒者的反应从严重焦虑到欣快。 这与男性酗酒者的反应相对应 在以前的研究中证明。 相比之下， 经历了m-CPP诱导的“饮酒欲望”反应， 据证实，大约40%的II型（早期） 男性酗酒者。