INTRAVENOUS PROCAINE IN ALCOHOLICS AND ADULT CHILDREN OF ALCOHOLICS

酗酒者和酗酒者的成年子女静脉注射普鲁卡因

• 批准号: 3767575
• 负责人: D GEORGE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767575
• 关键词: alcoholism /alcohol abuse; behavioral medicine; human subject; intravenous administration; limbic system; neuropharmacology; panic disorder; procaine; pulse pressure wave; vagus nerve

Previous studies show that the administration of procaine to bipolar and borderline patients gives rise to a diversity of behavioral responses ranging from euphoria to dysphoria. Since procaine is believed to selectively stimulate the limbic structures of the brain, it is reasoned that these behavioral differences might result from neuroclinical differences in these regions of the brain. To test the hypothesis that alcohol might alter limbic function we administered procaine to alcoholics, patients with panic disorder, panic patients with alcoholism and controls. Our results show that patients with panic disorder were more likely to experience a panic attack following procaine than were controls. Preliminary analysis of our results suggest that changes in vagal tone do not completely explain the rise in pulse frequency seen during a panic attack.

以前的研究表明，普鲁卡因的管理，以双极和 边缘型患者会产生多种行为反应 从欣快到烦躁 因为普鲁卡因被认为 有选择地刺激大脑的边缘系统， 这些行为差异可能是由神经临床 大脑中这些区域的差异。 为了验证这个假设， 酒精可能会改变边缘系统的功能， 酗酒者、惊恐障碍患者、酗酒的惊恐患者 和控制。 我们的研究结果表明，惊恐障碍患者 更有可能经历普鲁卡因后的恐慌发作， 对照 对我们结果的初步分析表明， 迷走神经张力不能完全解释脉冲频率的升高 在恐慌症发作的时候