YOHIMBINE CHALLENGE TO STUDY NORADRENERGIC FUNCTION IN INDIVIDUALS

育亨宾挑战研究个体去甲肾上腺素能功能

• 批准号: 2456606
• 负责人: D GEORGE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2456606
• 关键词: arousal; autonomic nervous system; clinical research; human subject; psychopharmacology; violence; yohimbine

Domestic violence is a major problem affecting society. Results from our research show that individuals who are physically abusive to their significant others frequently experience a hyperaroused state at the time of the violent act which is characterized by increased motor activity, heightened autonomic nervous system activity and accompanied by feelings of "being out of control". This hyperaroused state is similar to that which occurs in Post Traumatic Stress Disorder (PTSD). Since PTDS has been associated with changes in noradrenergic function, (1) we postulate that subjects who lose control and are physically violent may also have abnormal noradrenergic function. To test this hypothesis, we designed a study to compare the behavioral and biochemical effects resulting from the administration of the alpha-2 antagonist yohimbine between patients who lose control and are physically violent and comparison subjects.

家庭暴力是影响社会的一个主要问题。 源自我们的 研究表明，那些身体虐待他们的人， 重要的其他人经常会经历一个高度兴奋的状态， 暴力行为的特征是运动活动增加， 自主神经系统活动增强，并伴有感觉 “失去控制”。 这种高度兴奋的状态与 创伤后应激障碍（PTSD）。 由于PTDS已 与去甲肾上腺素能功能的变化有关，（1）我们假设 那些失去控制和身体暴力的人也可能有 去甲肾上腺素能功能异常 为了验证这一假设，我们设计了 一项研究，比较行为和生物化学的影响， 患者之间α-2拮抗剂育亨宾的给药 他们失去了控制，身体暴力，是比较对象。