PSYCHOLOGICAL/BIOLOGICAL CHARACTERIZATION OF SMOKING WITHDRAWAL IN ALCOHOLICS

酗酒者戒烟的心理/生物学特征

• 批准号: 2565427
• 负责人: D GEORGE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2565427
• 关键词: alcoholism /alcohol abuse; clinical research; human subject; neurotransmitter metabolism; psychobiology; smoking; smoking cessation; tobacco abuse

Alcoholics are more likely to smoke cigarettes than individuals without a drinking problem. In this protocol, we are studying neurotransmitter metabolite changes in recently abstinent alcoholics undergoing nicotine withdrawal verified by serum nicotine/cotinine concentrations. Alcoholics who continue to smoke or who are nonsmokers, nonalcoholic nonsmokers and smokers, make up the comparison groups. The results suggest decreased central noradrenergic turnover during nicotine withdrawal. In addition, there is increased central dopaminergic turnover in nonsmoking alcoholics. Mechanisms underlying these changes and allied changes in other neurotransmitters known to be affected by alcoholism are also being investigated. The results suggest that monoamines may be important in the neurobiological mechanisms of drug addiction.

酗酒者比不喝酒的人更有可能吸烟 饮酒问题。 在这个协议中，我们正在研究神经递质 最近戒酒的酗酒者接受尼古丁的代谢变化 通过血清尼古丁/可替宁浓度验证戒断。 继续吸烟或不吸烟、不酗酒的酗酒者 非吸烟者和吸烟者构成对照组。 结果 表明尼古丁期间中枢去甲肾上腺素能周转减少 撤回。 此外，中枢多巴胺能增加。 不吸烟的酗酒者的营业额。这些变化背后的机制 以及已知受其影响的其他神经递质的相关变化 酗酒问题也正在接受调查。 结果表明 单胺可能在药物的神经生物学机制中很重要 瘾。