RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING

用于核磁共振诊断成像的松弛剂

• 批准号: 3896316
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3896316
• 关键词: chelating agents; chemical conjugate; chemical synthesis; contrast media; gadolinium; magnetic resonance imaging; neoplasm /cancer diagnosis; noninvasive diagnosis; relaxation spectrometry

Nuclear Magnetic Resonance (NMR) imaging is a most powerful method for the non-invasive diagnosis of disease. A fundamental limitation of the technique derives from the fact that images are constructed from Tl relaxation time measurements of protons in the various biological "compartments". If T1 values for differing soft tissue types are similar, the types will not, in general, be resolvable in the images. A potential method for improving this situation is the development of relaxation agents which specifically alter T1 relaxation rates in tissues where they may be concentrated. We have recently shown that metal chelates are useful as an NMR contrast agent in myelography and cisternography. We have prepared a new and superior contrast agent, Gadolinium (Gd)DOTA. This chelate has recently been shown to be more stable in vivo than Gd(DTPA). This year, we report the preparation of new chelating ligands for linkage of contrast agents to proteins. An effective, efficient synthesis of 1-p-nitrobenzyl DOTA has been completed.

核磁共振（NMR）成像是一种最有力的方法， 非侵入性疾病诊断。一个基本的限制， 该技术源自图像是从T1构造的事实 在各种生物中质子的弛豫时间测量 “隔间”。如果不同软组织类型的T1值相似， 这些类型通常在图像中是不可分辨的。一个潜在 改善这种情况的方法是开发松弛剂 这特别改变了组织中的T1弛豫速率， 集中 我们最近表明，金属螯合物是有用的核磁共振对比 脊髓造影和脑池造影剂。我们准备了一个新的， 上级造影剂钆（Gd）DOTA。这种螯合物最近 在体内比Gd（DTPA）更稳定。 今年，我们报道了用于连接的新螯合配体的制备 对比剂和蛋白质的比例。一个有效的，高效的合成 1-对硝基苄基DOTA已完成。