RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING

核磁共振成像是一种最有效的方法 疾病的非侵入性诊断。从根本上限制了 这项技术源于这样一个事实，即图像是由TL构建的 不同生物中质子弛豫时间的测量 “舱室”。如果不同软组织类型的T1值相似， 通常，这些类型在图像中是不可解析的。一种潜力 改善这种状况的方法是开发松弛剂 它们可以特异性地改变组织中的T1弛豫速率 集中精力。 我们最近已经证明，金属络合物可用作核磁共振对比。 脊髓造影剂和脑池造影剂。我们已经准备了一个新的和 优越的造影剂--Gd-DOTA。这种络合物最近已经 在体内比Gd(DTPA)更稳定。 今年，我们报道了用于连接的新的螯合配体的制备 造影剂与蛋白质之间的相互作用。一种有效、高效的合成 1-对-硝基苄基DOTA已完成。

Nuclear Magnetic Resonance (NMR) imaging is a most powerful method for the non-invasive diagnosis of disease. A fundamental limitation of the technique derives from the fact that images are constructed from Tl relaxation time measurements of protons in the various biological "compartments". If T1 values for differing soft tissue types are similar, the types will not, in general, be resolvable in the images. A potential method for improving this situation is the development of relaxation agents which specifically alter T1 relaxation rates in tissues where they may be concentrated. We have recently shown that metal chelates are useful as an NMR contrast agent in myelography and cisternography. We have prepared a new and superior contrast agent, Gadolinium (Gd)DOTA. This chelate has recently been shown to be more stable in vivo than Gd(DTPA). This year, we report the preparation of new chelating ligands for linkage of contrast agents to proteins. An effective, efficient synthesis of 1-p-nitrobenzyl DOTA has been completed.