RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING

核磁共振成像正在迅速成为最强大的 疾病的非侵入性诊断方法。一个根本的限制 该技术的一部分源于这样一个事实，即从T1构造图像 不同生物中质子弛豫时间的测量 “舱室”。如果不同软组织类型的T1值相似， 一般说来，这种类型在图像中是不可分辨的。一种潜力 改善这种状况的方法是开发松弛剂 它们可以特异性地改变组织中的T1弛豫速率 集中精力。 不同金属对T_1驰豫的浓度依赖性研究 合成了络合物和有机氮氧自由基。基于这些 研究表明，金属络合物似乎更有效。 我们最近已经证明，这种金属络合物可用作核磁共振 脊髓造影术和脑池造影术的合同工。

Nuclear Magnetic Resonance (NMR) imaging is fast becoming a most powerful method for the non-invasive diagnosis of disease. A fundamental limitation of the technique derives from the fact that images are constructed from T1 relaxation time measurements of protons in the various biological "compartments". If T1 values for differing soft tissue types are similar, the type will not, in general, be reolvable in the images. A potential method for improving this situation is the development of relaxation agents which specifically alter T1 relaxation rates in tissues where they may be concentrated. A study of concentration dependence of T1 relaxation by various metal chelates and organic nitroxyl radicals has been prepared. Based on these studies, the metal chelates appear to be more efficient. We have recently shown that such metal chelates are useful as an NMR contract agent in myelography and cisternography.