RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING

用于核磁共振诊断成像的松弛剂

• 批准号: 4692107
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692107
• 关键词: chelating agents; chemical synthesis; neoplasm /cancer diagnosis; noninvasive diagnosis

Nuclear Magnetic Resonance (NMR) imaging is fast becoming a most powerful method for the non-invasive diagnosis of disease. A fundamental limitation of the technique derives from the fact that images are constructed from T1 relaxation time measurements of protons in the various biological "compartments". If T1 values for differing soft tissue types are similar, the type will not, in general, be reolvable in the images. A potential method for improving this situation is the development of relaxation agents which specifically alter T1 relaxation rates in tissues where they may be concentrated. A study of concentration dependence of T1 relaxation by various metal chelates and organic nitroxyl radicals has been prepared. Based on these studies, the metal chelates appear to be more efficient. We have recently shown that such metal chelates are useful as an NMR contract agent in myelography and cisternography.

核磁共振 (NMR) 成像正迅速成为最强大的技术 疾病的非侵入性诊断方法。 一个根本性的限制 该技术的原理源于图像是从 T1 构建的这一事实 各种生物中质子的弛豫时间测量 “隔间”。 如果不同软组织类型的 T1 值相似， 一般来说，该类型在图像中不可解析。 有潜力 改善这种情况的方法是开发松弛剂 它专门改变组织中可能存在的 T1 弛豫率 集中。 不同金属T1弛豫浓度依赖性的研究 已制备出螯合物和有机硝酰自由基。 基于这些 研究表明，金属螯合物似乎更有效。 我们最近证明这种金属螯合物可用作 NMR 脊髓造影和脑池造影的合同代理。