METAL CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
METAL CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
批准号:
4692108
负责人:
O A GANSOW
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
antitumor antibody chelating agents disease /disorder model drug design /synthesis /production immunoconjugates monoclonal antibody mouse leukemia neoplasm /cancer immunodiagnosis neoplasm /cancer radiodiagnosis neoplasm /cancer radionuclide therapy neoplasm /cancer transplantation radiopharmacology viral leukemia
中文摘要
肿瘤相关单抗是潜在的治疗药物
细胞毒剂对恶性细胞的选择性载体。我们正在测试
在几个动物模型系统中的这个假设:一个是肿瘤病毒
另一种是人肿瘤裸鼠移植瘤。
所使用的各种细胞杀伤剂是放射性同位素。他们的
与抗体结合时的相对治疗效果正在
对单抗进行检测和比较。所需的同位素
包括具有高度杀瘤活性的阿尔法发射母体
放射性同位素铅-212或铋-212。不同络合物的合成及应用
这些目标所需的放射化学分离正在设计中。
并简化为临床实践。同位素治疗的结果是
与使用抗体结合的毒素或药物获得的结果进行比较
关于肿瘤的生长、消退或治愈。
这些研究将为人类医学提供设计或
选择靶向细胞杀伤剂合理治疗恶性肿瘤
无论是肿瘤还是转移。
用于该项目的新的螯合物已经合成,并已在
测试,到目前为止已被证明对细胞的放射生物学研究有用
用α粒子标记抗体进行杀伤。
英文摘要
Tumor-associated monoclonal antibodies are potential therapeutic agents as
selective carriers of cytotoxic agents to malignant cells. We are testing
this hypothesis in serveral animal model systems: one is a tumor virus
leukemia of mice, another is human tumor xenographs in nude athymic mice.
The various cytocidal agents being employed are radioisotopes. Their
relative therapeutic efficacy when conjugated to antibodies is being
assayed and compared that of monoclonal antibodies alone. The isotopes to
be employed include the highly tumoricidal alpha emitting parent
radioisotopes Pb-212 or Bi-212. The syntheses of different chelates and
radiochemical separations required for these objectives are being devised
and reduced to clinical practice. Results from isotopic therapy are being
compared with those obtained by use of antibody conjugated toxins or drugs
with respect to tumor growth, regression or cure.
These studies will provide for human medicine a basis for design or
rational therapy of malignancies by selectively targeting cytocidal agents
to tumors as well as metastases.
New chelates for use in this project have been synthesized and are in
testing, and have thus far proven useful for Radiobiology studies of cell
killing with alpha particle labeled antibody.
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会议论文
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DX & THERAPY
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批准号:3916579
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3853176
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING
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批准号:3896316
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER
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批准号:3874417
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
IRON-57 NUCLEAR MAGNETIC RESONANCE--A NEW TOOL FOR BIOMEDICAL RESEARCH
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批准号:4692109
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3939518
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3752330
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS
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批准号:3916580
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3838054
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS FOR BIOMEDICAL RESEARCH
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批准号:3939519
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING
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批准号:4692107
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3963244
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS FOR BIOMEDICAL RESEARCH
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批准号:3963245
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:5201255
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DIAGNOSIS AND THERAPY
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批准号:3774569
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
METAL CHELATE CONJUGATED MONOCLONAL ANTIBODIES FOR TUMOR DX & THERAPY
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批准号:3874413
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING
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批准号:3916578
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING
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批准号:3939517
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING
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批准号:3963243
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:O A GANSOW
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依托单位:
海外基金