RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER

用于生产铱 194 Beta 发射体的放射性核素发生器

• 批准号: 3874417
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874417
• 关键词: beta radiation; biomedical equipment safety; clinical biomedical equipment; gamma radiation; iridium; neoplasm /cancer radiodiagnosis; neoplasm /cancer radionuclide therapy; neutron radiation; nuclear medicine; osmium; radiation dosage; radionuclide imaging /scanning; radionuclides; radiopharmacology; radiotracer

The project investigates the design, manufacturing, testing, and use of a novel radionuclide generator for biomedical applications. The generator has a long shelf-half-life, many years, and produces a 20-hour radionuclide daughter which emits high-energy beta particles that have suitable characteristics for labelling proteins through bifunctional chelates. In the 194-Os/1 94-Ir generator containing the parent nuclei, 194-Os has a halflife of 6.0 years which beta-decays, EmaxB=100 KeV, to the 19.15-hour 194-Ir daughter. The 194-Ir daughter decays with the emission of 2.2 MeV beta particles to the ground state of 194-Pt (86%) and to the 328.5 KeV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 KeV gamma-ray which follows the decay of 194-Ir with 13% absolute aboundance. The absence of high intensity gamma-rays in the decay of 194-Ir, with the exception to the 328.5 KeV, makes this beta emitter nuclei very attractive from the point of view of dosimetric considerations. On the other hand, the presence of 328.5 KeV gamma-rays makes 194-Ir a superior nuclei to 90-Y for tumor imaging. This year, Dr. Mirzadeh moved from the NIH to Oak Ridge National Laboratory where he has now completed work on the lridium-194 radionuclidic generator.

该项目调查了一种新型的 用于生物医学应用的新型放射性核素发生器。生成器已 半衰期长，可保存多年，产生20小时的放射性核素 它会发射出高能β粒子 通过双功能螯合物标记蛋白质的特性。 在含有母核的194-Os/194-Ir发生器中， β衰变的半衰期为6.0年，EmaxB=100 KeV，为19.15小时 第194章女儿194-Ir子体衰变，发射能量为2.2MeV β粒子的基态194-Pt（86%）和328.5 KeV 第一激发态，发射1.9 MeV β粒子（9.2%）。那里 是一个328.5 KeV的伽马射线，它遵循194-Ir的衰变， 绝对丰富。衰变中没有高强度的伽马射线 除了328.5 KeV的194-Ir外， 从剂量学考虑的观点来看，核是非常有吸引力的。 另一方面，328.5 KeV γ射线的存在使194-Ir成为 上级核比90-Y更适合肿瘤成像。 今年，Mirzadeh博士从NIH转到了橡树岭国家实验室 他现在已经在那里完成了铱-194放射性核素发生器的工作。