RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER

用于生产铱 194 Beta 发射体的放射性核素发生器

• 批准号: 3874417
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874417
• 关键词: beta radiation; biomedical equipment safety; clinical biomedical equipment; gamma radiation; iridium; neoplasm /cancer radiodiagnosis; neoplasm /cancer radionuclide therapy; neutron radiation; nuclear medicine; osmium; radiation dosage; radionuclide imaging /scanning; radionuclides; radiopharmacology; radiotracer

The project investigates the design, manufacturing, testing, and use of a novel radionuclide generator for biomedical applications. The generator has a long shelf-half-life, many years, and produces a 20-hour radionuclide daughter which emits high-energy beta particles that have suitable characteristics for labelling proteins through bifunctional chelates. In the 194-Os/1 94-Ir generator containing the parent nuclei, 194-Os has a halflife of 6.0 years which beta-decays, EmaxB=100 KeV, to the 19.15-hour 194-Ir daughter. The 194-Ir daughter decays with the emission of 2.2 MeV beta particles to the ground state of 194-Pt (86%) and to the 328.5 KeV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 KeV gamma-ray which follows the decay of 194-Ir with 13% absolute aboundance. The absence of high intensity gamma-rays in the decay of 194-Ir, with the exception to the 328.5 KeV, makes this beta emitter nuclei very attractive from the point of view of dosimetric considerations. On the other hand, the presence of 328.5 KeV gamma-rays makes 194-Ir a superior nuclei to 90-Y for tumor imaging. This year, Dr. Mirzadeh moved from the NIH to Oak Ridge National Laboratory where he has now completed work on the lridium-194 radionuclidic generator.

该项目调查设计、制造、测试和使用 用于生物医学的新型放射性核素发生器。发电机有 保质期长，半衰期长，长达数年，可产生20小时的放射性核素 释放出高能贝塔粒子的子体 双功能络合物标记蛋白质的特性。 在含有母核的194-Os/194-Ir发生器中，194-Os有一个 β衰变的半衰期为6.0年，Emax B=100keV，到19.15小时 194-IR的女儿。194-Ir子体衰变，发射量为2.2 MeV β粒子到194-铂的基态(86%)和到328.5 keV 发射1.9 MeVβ粒子的第一激发态(9.2%)。那里 是一条328.5 keV的伽马射线，它跟随194-Ir的衰变，有13% 绝对充足。衰变中没有高强度的伽马射线 除了328.5 keV外，194-Ir是这种测试型发射器 从剂量学的角度来看，原子核非常吸引人。 另一方面，328.5 keV伽马射线的存在使194-Ir成为 优于90-Y的核团用于肿瘤成像。 今年，米尔扎德博士从美国国立卫生研究院调到橡树岭国家实验室 在那里，他现在已经完成了Ir-194放射性核素发生器的工作。