IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS

我们正在开发铁-57和氘核磁共振 (NMR)作为生物医学科学的实验方法。 血液中发现的许多化合物都含有铁核心。 其中 是细胞色素、血红蛋白或铁氧蛋白。 少量化学品 方法可用于直接研究中心金属原子 这些蛋白质的环境。 铁-57核磁共振正在开发中， 这个目的。 前一段时间，我们报道了铁-57 NMR用于研究 一些铁化合物的弛豫时间和化学位移 生物实体。 我们这样确定了基本参数 需要进一步研究铁核磁共振。 我们目前努力发展的方法包括合成 一系列弱磁性铁-57富集化合物。 努力 来观察金属共振现象

We are developing iron-57 and deuterium Nuclear Magnetic Resonance (NMR) as an experimental method for use in the Biomedical Sciences. Many compounds found in the blood contain iron cores. Among these are the cytochromes, hemoglobin, or ferridoxin. Few chemical methods may be used to directly study the central metal atom environments of these proteins. Iron-57 NMR is being developed for that purpose. Some time ago, we reported the utility of iron-57 NMR for study of relaxation times and chemical shifts of some iron compounds related to biological entities. We determined thus the basic parameters needed for further study of iron NMR. Our current efforts to develop the method have involved synthesis of series of weakly magnetic iron-57 enriched compounds. Efforts to observe the metal resonance are underway.