RELAXATION AGENTS FOR NMR DIAGNOSTIC IMAGING

核磁共振成像是一种最有效的方法 用于疾病的非侵入性诊断。一项基本原则 该技术的局限性源于这样一个事实：图像 由T1弛豫时间测量的质子构成 各种生物“隔间”。如果不同软体的T1值不同 组织类型相似，通常情况下，类型不会是 可在图像中解析。一种改善这一状况的潜在方法 情况是松弛剂的发展 特别是改变组织中的T1弛豫速率，在这些组织中，他们可能 集中精神。 我们最近已经证明金属络合物作为核磁共振是有用的 脊髓造影术和脑池造影术中的造影剂。我们已经准备好了 一种新型的高性能造影剂--Gd-DOTA。这 最近研究表明，螯合物在体内比在体内更稳定。 Gd(DTPA)。 今年，我们报道了造影剂的一些新的应用 活体磁共振成像。

Nuclear Magnetic Resonance (NMR) imaging is a most powerful method for the non-invasive diagnosis of disease. A fundamental limitation of the technique derives from the fact that images are constructed from T1 relaxation time measurements of protons in the various biological "compartments". If T1 values for differing soft tissue types are similar, the type will not, in general, be resolvable in the images. A potential method for improving this situation is the development of relaxation agents which specifically alter T1 relaxation rates in tissues where they may be concentrated. We have recently shown that metal chelates are useful as an NMR contrast agent in myelography and cisternography. We have prepared a new and superior contrast agent, Gadolinium (Gd)DOTA. This chelate has recently been shown to be more stable in vivo than Gd(DTPA). This year, we report some new applications of contrast agents for in vivo MRI imaging.