IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS FOR BIOMEDICAL RESEARCH

我们正在开发铁-57和氘核磁

We are developing iron-57 and deuterium Nuclear Magnetic Resonance (NMR) as an experimental method for use in the Biomedical Sciences. Many compounds found in the blood contain iron cores. Among these are the cytochromes, hemoglobin, or ferridoxin. Few chemical methods may be used to directly study the central metal atom environments of these proteins. Iron-57 NMR is being developed for that purpose. Some time ago, we reported the utility of iron-57 NMR for study of relaxation times and chemical shifts of some iron compounds related to biological entities. We determined thus the basic parameters needed for further study of iron NMR. Our current efforts to extend this project to include an examination of the field dependent H-2 NMR of iron porphyrins as a companion method to iron NMR have resulted in measurements of anisotropies on iron porphyrins partially oriented in a magnetic field.