MATURATION AND PLASTICITY IN THE OLFACTORY SYSTEM

嗅觉系统的成熟和可塑性

• 批准号: 3406357
• 负责人: PETER C BRUNJES
• 金额: $ 6.56万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3406357
• 关键词: autoradiography; biochemical evolution; brain metabolism; cell growth regulation; developmental neurobiology; gene expression; hippocampus; histochemistry /cytochemistry; immunochemistry; laboratory rat; limbic system; neural plasticity; neuroanatomy; neurochemistry; neurotransmitters; olfactory lobe; oxidation; protein biosynthesis; synapses

Olfactory sensitivity has been demonstrated to be important for directing a number of early behaviors in many mammalian species. While the role of chemosensitivity in behavioral development has been well studied, relatively little is known about the ontogeny of the principal relay in the olfactory system, the olfactory bulb. One purpose of the proposed research is to begin thorough anatomical, neurochemical and biochemical studies of bulb development in order to better understand maturation in this important sensory modality. A second purpose of the studies is to use the olfactory bulb to examine how experiential factors regulate brain development. While it has been demonstrated repeatedly that environmental input is important in shaping patterns of neural maturation, relatively little research has examined the cellular events through which the shaping occurs. The present grant is designed to pursue these issues by examining the effects of unilateral deprivation on the development of the olfactory bulb. Two specific problems will be addressed. First, the proposed studies will examine the sequence of postsynaptic events resulting from decreased airflow over the olfactory receptors. These studies will lead to an enhanced understanding of the mechanisms of experience-induced change. Second, the proposed studies will help to define which aspects of bulb development are experientially sensitive and which are independent in order to determine why experience has such important effects on neural growth at some stages in life and little at others. Quantitative neuroanatomical, neurochemical and biochemical techniques will also be used in these studies. The proposed experiments will help define normal and experientially modified growth in a primary sensory nucleus which has received relatively little attention. The findings will have important implications for our conceptions of early brain function, normal brain development and the cellular interactions through which environmental events control the patterning of brain growth.

嗅觉敏感度已被证明对

项目成果

A comparative study of myelination in precocial and altricial murid rodents.

• DOI: 10.1016/0165-3806(88)90159-9
• 发表时间: 1988-09
• 期刊: Brain research
• 影响因子: 2.9
• 作者: C. Tessitore;P. Brunjes

Early postnatal differentiation of granule cell dendrites in the olfactory bulbs of normal and unilaterally odor-deprived rats.

正常和单侧气味剥夺大鼠嗅球中颗粒细胞树突的出生后早期分化。

• DOI: 10.1016/0165-3806(89)90115-6
• 发表时间: 1989
• 期刊: Brain research. Developmental brain research
• 作者: Frazier-Cierpial,LL;Brunjes,PC
• 通讯作者: Brunjes,PC

A comparative study of prenatal development in the olfactory bulb, neocortex and hippocampal region of the precocial mouse Acomys cahirinus and rat.

早熟小鼠和大鼠嗅球、新皮质和海马区产前发育的比较研究。

• DOI: 10.1016/0165-3806(89)90055-2
• 发表时间: 1989
• 期刊: Brain research. Developmental brain research
• 作者: Brunjes,PC

NADPH diaphorase staining within the developing olfactory bulbs of normal and unilaterally odor-deprived rats.

正常和单侧气味剥夺大鼠发育中的嗅球内的 NADPH 黄酶染色。

• DOI: 10.1016/0006-8993(88)90376-9
• 发表时间: 1988
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Croul-Ottman,CE;Brunjes,PC
• 通讯作者: Brunjes,PC