BIOLOGY OF HUMAN AIDS RETROVIRUS
BIOLOGY OF HUMAN AIDS RETROVIRUS
批准号:
5200474
负责人:
B CHESEBRO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AIDS dementia complex CD4 molecule HeLa cells genetic polymorphism human immunodeficiency virus human tissue macrophage microglia microorganism culture molecular cloning nucleic acid sequence plasmids protein sequence virulence virus envelope virus genetics virus infection mechanism virus replication
中文摘要
人类免疫缺陷病毒(HIV)在临床上引起多种疾病
英文摘要
Human immunodeficiency virus (HIV) causes a variety of clinical
manifestations such as opportunistic infection, Kaposi's sarcoma, wasting
syndrome, and neurological defects. The main goal of this project is to
determine the role of variation in viral sequences in causing these
different syndromes.
In the past year brain samples from a prospective clinical study on HIV
dementia were used to identify significant sequences in HIV envelope C2
and V3 regions which differed in demented and nondemented AIDS patients.
Sequences from both groups were also cloned in infectious plasmids and
were found to be macrophage-tropic in all cases. These results are
consistent with the interpretation that most HIV strains present in brain
are macrophage-tropic strains which infect brain microglial cells, but
HIV dementia appears to correlate with the appearance of a unique subset
of macrophage-tropic viruses which cause dementia via as yet unknown
mechanisms.
More recent studies have focussed on in vitro infection of human
macrophages by HIV strains which vary in replication levels in
macrophages. This variation was found to occur only in macrophages and
not in lymphocytes, and it correlated with sequence differences in the
envelope V1 and V2 regions. Immunostaining of virus-positive cells at
various times after infection showed that high replication levels were
due to viral spread in the macrophages whereas low replication levels
were seen in viruses which were unable to spread to new cells after
initial infection. These two replication phenotypes have been seen in
primary AIDS patient HIV isolates and might play different roles in in
vivo pathogenesis.
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IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:4688533
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:3960601
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3822091
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3818247
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:2566698
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:3818225
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:2566777
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3790761
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:6160542
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:6160616
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3746544
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3960632
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3809661
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3803190
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
海外基金