IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
批准号:
3960601
负责人:
B CHESEBRO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AIDS Retroviridae antibody formation antibody neutralization test antibody specificity antiviral antibody blood cells disease /disorder model equine infectious anemia virus genetic recombination genetic strain hemolytic anemia immunosuppression microorganism immunology monoclonal antibody mutant virus antigen virus diseases virus genetics virus infection mechanism
中文摘要
抗原变异已被建议作为一种手段
慢病毒,包括马传染性贫血病毒 (EIAV)、艾滋病
逆转录病毒和维斯纳病毒,尽管存在
病毒特异性宿主免疫反应。 该项目的目标是
阐明遗传基因的产生和选择的重要因素
以及 EIAV 的抗原变体关于变异的作用
病毒的持续存在和疾病的发病机制。 我们回收了分离株
EIAV 来自两个早期临床疾病周期的实验
被感染的马。 这些分离株被发现是遗传变异
通过 RNase T1 抗性寡核苷酸指纹分析确定。
此外,分离株可以通过抗体进行抗原区分
它与病毒感染细胞的表面结合,支持了这一概念
识别新兴病毒的抗体的连续开发
变体。 然而,在早期,没有检测到中和抗体,
从中分离出这些变体的发热期。 相反,
中和抗体是在病程后期检测到的,但是
对后来出现的病毒变种具有特异性的中和抗体是
在中和针对早期出现的特异性抗体之前检测到
变体。 这些结果表明中和可能不是
选择 EIAV 变体的机制。 然而,非中和
抗病毒抗体仍可能通过识别和识别来选择变异体
消除某些病毒感染的细胞。 或者,抗体
特异性可能是对病毒变异的反应,而不是病毒变异的原因
体内。 试图更清楚地定义抗体在
选择病毒变体,我们计划分析遗传和抗原
我们从连续检测中发现的 6 种 EIAV 分离株的相关性
实验感染马的发热期。
英文摘要
Antigenic variation has been suggested as a meas by which several
lentiviruses, including equine infectious anemia virus (EIAV), AIDS
retrovirus and visna virus, are able to persist in spite of a
virus-specific host immune response. The goal of this project is to
elucidate the factors important in the generation and selection of genetic
and antigenic variants of EIAV with regard to the role of variation in
viral persistence and the pathogensis of disease. We recovered isolates of
EIAV from two early cycles of clinical disease in an experimentally
infected horse. These isolates were found to be genetic variants as
determined by RNase T1 resistant oligonucleotide fingerprint analysis.
Furthermore, the isolates could be antigenically distinguished by antibody
which bound to the surface of virus-infected cells, supporting the concept
of a sequential development of antibody which recognizes emerging viral
variants. However, no neutralizing antibody was detected during the early,
febrile periods from which these variants were isolated. Instead,
neutralizing antibody was detected later in the course of disease, but
neutralizing antibody specific for the later appearing virus variant was
detected prior to neutralizing antibody specific for the earlier appearing
variant. These results suggested that neutralization might not be the
mechanism for selection of EIAV variants. However, non-neutralizing
antiviral antibody might still select for variants through recongition and
elimination of certain virus-infected cells. Alternatively, the antibody
specificity may be a response to, rather than a cause of, viral variation
in vivo. In an attempt to more clearly define the role of antibody in the
selection of viral variants, we plan to analyze the genetic and antigenic
relatedness of six isolates of EIAV which we recovered from consecutive
febrile periods of an experimentally infected horse.
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IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:4688533
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3822091
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3818247
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:2566698
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:3818225
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:2566777
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3790761
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:6160542
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:6160616
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3746544
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:5200474
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3960632
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3803190
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3809661
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位: