BIOLOGY OF HUMAN AIDS RETROVIRUS
BIOLOGY OF HUMAN AIDS RETROVIRUS
批准号:
6160616
负责人:
B CHESEBRO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
这个项目的主要目标是确定变异的作用
英文摘要
The primary goal of this project is to determine the role of variation
in HIV sequences in causing the various clinical manifestations seen in
AIDS. Variation in the polymerase gene associated with resistance to
certain drug combinations have been studied by molecular cloning and in
vitro analysis of drug resistance. The role of individual amino acid
alterations has been determined by these studies. Variation in the
envelope gene has been studied both in vivo and in vitro. In vivo env
sequence analysis of viruses associated with dementia suggested that
unique viral strains may be responsible for the occurrence of HIV
dementia. In contrast, other analyses indicated that dementia was not
associated with higher levels of viral DNA. The influence of the V3
region of the envelope gene on macrophage tropism and the NSI and SI
phenotypes was mapped to individual V3 amino acids, and it was found
that usually macrophage tropism and the SI phenotype were independently
determined by amino acids at different V3 positions. This finding
provides an explanation for the occurrence of HIV strains which exhibit
both the SI phenotype and macrophage tropism.
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IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:4688533
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:3960601
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3822091
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3818247
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:2566698
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
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批准号:3818225
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:2566777
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3790761
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
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批准号:6160542
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:5200474
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3746544
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3960632
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3809661
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
BIOLOGY OF HUMAN AIDS RETROVIRUS
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批准号:3803190
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B CHESEBRO
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依托单位:
海外基金