MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS

鼠友白血病病毒的发病机制和恢复机制

• 批准号: 6160542
• 负责人: B CHESEBRO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160542
• 关键词: Friend leukemia; Friend virus; helper virus; histocompatibility antigens; histocompatibility gene; host organism interaction; immunogenetics; laboratory mouse; microorganism culture; microorganism immunology; murine leukemia virus; recombinant virus; virulence; virus antigen; virus envelope; virus genetics

Mechanisms of recovery from leukemia induced by retroviral infection have been studied in the Friend murine leukemia virus system. Viral genes in both the helper and defective components of Friend virus complex have been examined to determine their respective roles in generation of and recovery from erythroleukemia . In addition, host genes influencing the anti-viral immune response including those in the major histocompatibility complex (H-2A, E, D, and T) and non-MHC genes such as Rfv-3 have also been studied to identify the mechanisms of elimination of both virus and leukemia cells. In a separate aspect of the project retrovirus-induced brain disease has been studied using polytropic retroviruses derived from Friend murine leukemia virus. This work has focused on analysis of the cell specificity of virus infection and the pathology produced in the central nervous system. Furthermore, the role of various regions of the viral envelope gene in mediating disease has been studied using detailed mapping studies.

逆转录病毒感染诱导白血病恢复的机制 已经在Friend鼠白血病病毒系统中进行了研究。 病毒 Friend病毒的辅助和缺陷成分中的基因 综合体已被审查，以确定其各自的作用， 红白血病的产生和恢复。此外，东道主 影响抗病毒免疫反应的基因，包括那些在 主要组织相容性复合体（H-2A、E、D和T）和非MHC基因 如Rfv-3也被研究，以确定机制， 清除病毒和白血病细胞。 在该项目的另一个方面，逆转录病毒引起的脑部疾病 使用来自Friend鼠的多嗜性逆转录病毒进行了研究 白血病病毒这项工作的重点是分析细胞 病毒感染的特异性和病理产生的 中枢神经系统此外，各区域的作用 病毒包膜基因在介导疾病中的作用已被详细研究， 测绘研究。