FLOW CYTOMETRIC ANALYSIS OF BENIGN AND MALIGNANT TUMORS

我们研究了标本中非整倍体和S期的存在。 含有Zollinger-Ellison综合征患者的胃泌素瘤。全 多干系非整倍体患者有广泛的疾病，而 所有具有单一非整倍体群体的患者都有局部性疾病。 疾病与倍性显著相关，P=0.00022。 我们的发现还表明，倍性可能对预后有重要意义。 患者存活率；然而，更长的随访时间和更多的 患者是必要的，以确定这是否显著。高S相 与广泛性疾病显著相关(P=0.0039)。因此， 胃泌素瘤的DNA含量分析提供了重要信息 可供临床医生在治疗决策中使用。更具侵略性 多发性干系非整倍体或高S期患者的治疗 防止转移和传播疾病。 我们正在研究儿童甲状腺癌的DNA含量和 受切里诺布尔地区辐射污染的成年人 事故，美国有辐射史的成年人 暴露，以及没有辐射暴露史的美国成年人。我们 将研究辐射暴露史与 甲状腺癌中非整倍体和S期的发生率。这个 DNA含量分析在这些肿瘤中的预后价值 已评估。这一信息也可能有助于早期发现 甲状腺癌是本病的高危人群，因 职业源或治疗源的辐射照射。 我们正在完成一项关于DNA含量分析的预后价值的研究 在一组淋巴结阴性的乳腺癌中。这是一个 有争议的研究领域，许多研究都是复杂的 研究人群和所接受治疗的差异。我们的 患者是来自阿根廷的同种人群，他们都是 由同一个临床医生治疗。此测试目前正由 肿瘤学家在乳腺癌辅助化疗中的评价 预防转移疾病。有必要进一步研究，以澄清 这项检测的预后价值。

We have studied the presence of aneuploidy and S phase in specimens containing gastrinomas from patients with Zollinger-Ellison syndrome. All patients with multiple stem line aneuploidy had widespread disease while all patients with a single aneuploid population had localized disease. The correlation between disease and ploidy was significant with P=0.00022. Our findings also suggest that ploidy may be of prognostic importance in patient survival; however, a longer follow-up time and greater number of patients is necessary to determine if this is significant. High S-phase correlated significantly with widespread disease (P=0.0039). Therefore, DNA content analysis of gastrinomas provides important information that can be utilized by the clinicians in treatment decisions. More aggressive therapy in patients with multiple stem line aneuploidy or high S-phase may prevent metastases and widespread disease. We are studying the DNA content of thyroid carcinomas from children and adults in the region contaminated with radiation from the Cherynobl accident, adults in the United States with a history of radiation exposure, and American adults with no history of radiation exposure. We will study the correlation between a history of radiation exposure and the incidence of aneuploidy as well as S phase in thyroid carcinoma. The prognostic value of DNA content analysis in these tumors will be evaluated. This information may also be useful in early detection of thyroid carcinoma in patients at high risk for this disease due to radiation exposure from occupational or therapeutic sources. We are completing a study on the prognostic value of DNA content analysis in a group of lymph node negative breast carcinomas. This is a controversial area of research with many studies complicated by differences in the population studied and treatment received. Our patients are a homogeneous population from Argentina that have all been treated by the same clinician. This test is currently being used by oncologists in evaluation of breast cancer for adjuvant chemotherapy to prevent metastatic disease. Further study is necessary to clarify the prognostic value of this test.