ANEUPLOIDY AND CELL CYCLE FRACTIONS IN BENIGN AND MALIGNANT TUMORS

良性和恶性肿瘤中的非整倍性和细胞周期分数

• 批准号: 3774419
• 负责人: M STETLER-STEVENSON
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774419
• 关键词: DNA; DNA replication; Zollinger Ellison syndrome; aneuploidy; breast neoplasm /cancer diagnosis; breast neoplasms; carcinoma; cell cycle; cellular oncology; cellular pathology; disease /disorder proneness /risk; gastrointestinal neoplasms; human tissue; neoplasm /cancer genetics; prognosis; radiation hazard; radiation related neoplasm /cancer; thyroid neoplasm

We have studied the presence of aneuploidy and S phase in specimens containing gastrinomas from patients with Zollinger-Ellison syndrome. All patients with multiple stem line aneuploidy had widespread disease while all patients with a single aneuploid population had localized disease. The correlation between disease and ploidy was significant with P=0.00022. Our findings also suggest that ploidy may be of prognostic importance in patient survival; however, a longer follow-up time and greater number of patients is necessary to determine if this is significant. High S-phase correlated significantly with widespread disease (P=0.0039). Therefore, DNA content analysis of gastrinomas provides important information that can be utilized by the clinicians in treatment decisions. More aggressive therapy in patients with multiple stem line aneuploidy or high S-phase may prevent metastases and widespread disease. We are studying the DNA content of thyroid carcinomas from children and adults in the region contaminated with radiation from the Cherynobl accident, adults in the United States with a history of radiation exposure, and American adults with no history of radiation exposure. We will study the correlation between a history of radiation exposure and the incidence of aneuploidy as well as S phase in thyroid carcinoma. The prognostic value of DNA content analysis in these tumors will be evaluated. This information may also be useful in early detection of thyroid carcinoma in patients at high risk for this disease due to radiation exposure from occupational or therapeutic sources. We are completing a study on the prognostic value of DNA content analysis in a group of lymph node negative breast carcinomas. This is a controversial area of research with many studies complicated by differences in the population studied and treatment received. Our patients are a homogeneous population from Argentina that have all been treated by the same clinician. This test is currently being used by oncologists in evaluation of breast cancer for adjuvant chemotherapy to prevent metastatic disease. Further study is necessary to clarify the prognostic value of this test.

我们研究了标本中非整倍体和S期的存在 含有来自Zollinger-Ellison综合征患者的胃泌素瘤。 所有 具有多个干细胞系非整倍体的患者具有广泛的疾病， 具有单一非整倍体群体的所有患者具有局部疾病。 疾病与倍性之间的相关性是显著的，P=0.00022。 我们的研究结果还表明，倍性可能是预后的重要性， 患者生存率;然而，更长的随访时间和更多的 患者需要确定这是否重要。 高S相 与广泛性疾病显著相关（P=0.0039）。 因此，我们认为， 胃泌素瘤的DNA含量分析提供了重要信息， 可以被临床医生用于治疗决策。 更积极 多个干细胞系非整倍体或高S期患者的治疗可能 防止转移和广泛的疾病。 我们正在研究儿童甲状腺癌的DNA含量， 受切尔诺贝利核辐射污染的成年人 事故，在美国有辐射史的成年人 暴露，以及没有辐射暴露史的美国成人。 我们 将研究辐射暴露史与 甲状腺癌中异倍体和S期的发生率。 的 DNA含量分析在这些肿瘤中的预后价值将是 评估。 这些信息也可能有助于早期发现 甲状腺癌患者在这种疾病的高风险，由于 职业或治疗来源的辐射暴露。 我们正在完成一项关于DNA含量分析的预后价值的研究 一组淋巴结阴性乳腺癌。 这是一 这是一个有争议的研究领域， 研究人群和接受治疗的差异。 我们 患者是来自阿根廷的同质人群， 由同一位临床医生治疗。 该测试目前正在由 肿瘤学家评估乳腺癌辅助化疗， 预防转移性疾病。 需要进一步研究，以澄清 这个测试的预测价值。