TIMP-1 EXPRESSION BY NORMAL LYMPHOCYTES AND IN LYMPHOID NEOPLASMS

正常淋巴细胞和淋巴肿瘤中的 TIMP-1 表达

• 批准号: 3796582
• 负责人: M STETLER-STEVENSON
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3796582
• 关键词: B lymphocyte; Burkitt's lymphoma; T lymphocyte; antibody; athymic mouse; cell cycle; cell type; clone cells; gene expression; human tissue; lymphoma; messenger RNA; metalloenzyme; neoplasm /cancer classification /staging; neoplasm /cancer genetics; protease inhibitor

We have observed the expression of TIMP-1 at the RNA level in hyperplastic tonsils, activated T-cells and some Burkitt cell lines. TIMP-1 was not expressed by numerous T-cell lines or B-cell lines derived from low-grade lymphomas. We have demonstrated secretion of TIMP-1 protein by these Burkitt cell lines and observed that TIMP-1 expression correlates with cell proliferation rates. We are currently studying the effect of TIMP-1 on the kinetics of cell proliferation in the Burkitt cell lines as well as the aggressiveness of these lines in nude mice. We are undertaking a study of the expression of TIMP-1 in aggressive and low-grade B-cell neoplasms using antibodies against TIMP-1.

我们在增生性组织中观察到 TIMP-1 在 RNA 水平的表达。 扁桃体、活化的 T 细胞和一些 Burkitt 细胞系。 TIMP-1 不是 由许多源自低级的 T 细胞系或 B 细胞系表达 淋巴瘤。 我们已经证明这些细胞可以分泌 TIMP-1 蛋白 Burkitt 细胞系并观察到 ​​TIMP-1 表达与细胞相关 增殖率。 我们目前正在研究 TIMP-1 对 Burkitt 细胞系的细胞增殖动力学以及 这些品系在裸鼠中的攻击性。 我们正在进行一项研究 使用 TIMP-1 在侵袭性和低级别 B 细胞肿瘤中的表达 TIMP-1 抗体。