UTILIZATION OF SPECIALIZED HARDWARE FOR DNA SEQUENCE ANALYSIS

DCRT正在提供一个应用生物系统公司。Inherit（TM）系统 作为NIH内部研究社区的共享资源。该系统 采用客户端/服务器架构，使用Apple Macintosh计算机作为 客户平台。科学家可以从ABI购买客户端软件， 通过NIH网络访问Inherit（TM）系统。 为了加快结果，Inherit（tm）使用高度专业化的硬件。 快速数据并行处理器FDF（Fast Data Array）是一种并行处理器， 以超过1500万的速度在大型数据库中进行匹配搜索 每秒字符数这种速度允许在几个小时内完成任务 这通常需要使用功能强大的UNIX（TM）工作站数天。 该系统最适合于：（1）组装中大型序列： (2)在基因和蛋白质数据库中搜索序列同源性;和（3） 快速搜索遗传基序，如调节元件。一个组成 模式描述语言允许构造非常复杂的查询。 DCRT向ABI提供了大量反馈，以改进客户端用户 接口，并探讨了将客户端软件移植到 其他平台，如UNIX（tm）工作站或NIH CONVEX/SGI server. 该项目突出了NIH网络带来强大的 和复杂的资源通过台式电脑到科学家的 工作台 Inherit是Applied Biosystems，Inc.的商标。 UNIX是X-Open的商标。

DCRT is making available an Applied Biosystems, Inc. Inherit (tm) system as a shared resource to the NIH intramural research community. This system employs a client/server architecture using an Apple Macintosh computer as the client platform. Scientists can purchase client software from ABI and access the Inherit (tm) system over the NIH network. To speed results, Inherit (tm) makes use of highly specialized hardware. The Fast Data Finder (FDF) parallel processor can perform parallel pattern matching searches through large databases at a rate of over 15 million characters per second. This speed permits completion in hours of tasks that often require days using powerful UNIX (tm) workstations. The system is best suited to: (1) assembly of medium to large sequences: (2) searching gene and protein databases for sequence homologies; and (3) rapid searches for genetic motifs such as regulatory elements. An integral pattern description language permits construction of very complex queries. DCRT has provided considerable feedback to ABI to improve the client user interface, and has explored the possibility of porting client software to additional platforms, such as UNIX (tm) workstations or the NIH CONVEX/SGI server. This project highlights the potential of the NIH network to bring powerful and sophisticated resources through desktop computers to the scientist's benchtop. Inherit is a trademark of Applied Biosystems, Inc. UNIX is a trademark of X-Open.