UTILIZATION OF SPECIALIZED HARDWARE FOR DNA SEQUENCE ANALYSIS

DCRT正在提供一个应用生物系统公司。继承系统作为 NIH内部研究社区的共享资源。 该系统 使用Apple Macintosh计算机的客户机/服务器架构 作为客户端平台。 科学家可以购买Macintosh客户端 软件，并通过NIH网络访问Inherit系统。 为了加快结果，Inherit使用了高度专业化的硬件。 的 FDF并行处理器可以执行并行模式 以超过1500万的速度在大型数据库中进行匹配搜索 每秒字符数 这种速度允许在几个小时内完成任务 这通常需要使用普通工作站的数天时间。 此系统最适合于：（1）组装中大型测序 （2）在基因和蛋白质数据库中搜索同源的 基因序列;以及（3）快速搜索遗传基序， 监管要素。 一种模式搜索语言， 系统允许构造非常复杂的查询。 该项目突出了NIH网络带来的潜力， 强大而复杂的计算资源， 电脑到科学家的工作台。 Inherit是Perkin Elmer，Inc.的商标。

DCRT is making available an Applied Biosystems, Inc. Inherit system as a shared resource to the NIH intramural research community. This system employs a client/server architecture using an Apple Macintosh computer as the client platform. Scientists can purchase Macintosh client software from ABI and access the Inherit system over the NIH network. To speed results, Inherit makes use of highly specialized hardware. The Fast Data Finder (FDF) parallel processor can perform parallel pattern matching searches through large databases at a rate of over 15 million characters per second. This speed permits completion in hours of tasks which often require days using general workstations. This system is best suited to: (1) assembly of medium to large sequencing projects; (2) searching the gene and protein databases for homologous gene sequences; and (3) rapid searches for genetic motifs such as regulatory elements. A pattern search language incorporated in the system permits construction of very complex queries. This project highlights the potential of the NIH network to bring powerful and sophisticated computational resources through the desktop computer to the scientist's benchtop. Inherit is a trademark of Perkin Elmer, Inc.