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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT

STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
免疫球蛋白基因重排的研究
批准号：
3754210
负责人：
M GELLERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3754210
关键词：
antigen receptors enzyme substrate gene deletion mutation gene rearrangement immunoglobulin genes laboratory mouse molecular site nucleic acid structure protein structure function

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英文摘要
The products of the RAG-1 and RAG-2 genes are known to be the only lymphoid-specific factors required for the rearrangement of antigen receptor genes (generally known as V(D)J recombination). We have made a large number of mutations in the mouse RAG-1 and RAG-2 genes, for the purpose of understanding the functions of different parts of the proteins. So far, we have learned that large parts of both proteins are dispensable for recombination activity. The N-terminal 35% of RAG-1 can be removed without a significant decrease of activity; similarly, the C- terminal 25% of RAG-2 is not essential. The deleted regions include a zinc-finger motif in RAG-1 and a highly acidic sequence in RAG-2, which are thus shown to be non-essential.
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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