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STUDY OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION

STUDY OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
基因重组相关功能的研究
批准号：
3875872
负责人：
M GELLERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3875872
关键词：
DNA DNA gyrase adenosine triphosphate affinity labeling chemical binding enzyme inhibitors enzyme mechanism enzyme structure genetic manipulation genetic recombination lysine nucleic acid structure pyridoxal phosphate

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中文摘要
翻译
DNA促旋酶的ATP结合位点（在B亚基上）已经通过 使用亲和标记。腺苷酰磷酸吡哆醛标记试剂 在位置103和110处的两个赖氨酸，在与一些具有弱同源性的区域中， 其他ATP 另一种ATP类似物，（β，γ-亚氨基）ATP，通过以下方式抑制DNA促旋酶： 可逆结合，已显示与酶结合非常缓慢， 与快速结合的ATP相反。
英文摘要
The ATP-binding site of DNA gyrase (on the B subunit) has been located by use of an affinity label. The reagent adenylyl-pyridoxal phosphate labels two lysines at positions 103 and 110 in a region with weak homology to some other ATPases. Another ATP analog, (beta, gamma-imido) ATP, which inhibits DNA gyrase by binding reversibly, has been shown to bind very slowly to the enzyme, in contrast to ATP whose binding is rapid.
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会议论文
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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