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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT

STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
免疫球蛋白基因重排的研究
批准号：
3940666
负责人：
M GELLERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3940666
关键词：
B lymphocyte antibody formation bacterial DNA bioassay gene expression genetic manipulation genetic recombination immunoglobulins molecular biology nucleic acid sequence plasmids tissue /cell culture

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英文摘要
The level of immunoglobulin gene V-J recombination activity in cell lines derived from lymphoid or nonlymphoid lineages was examined. The assay uses an extrachromosomal DNA substrate, and thus avoids difficulties associated with the use of chromosomally integrated DNA. The recombination activity is found to vary progressively during B lymphoid development. It is low at a very early stage (pro-GMB), much higher in pro-B cells, but then declines through later stages, reaching an undetectable level in mature B cells. The activity is also present in multi potential progenitors of myeloid cells, and in pre-T but not mature T cells. No activity was found in several nonhematopoietic cell lines.
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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