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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT

STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
免疫球蛋白基因重排的研究
批准号：
5201975
负责人：
M GELLERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5201975
关键词：
DNA binding protein antigen receptors cell free system enzyme mechanism gene rearrangement immunoglobulin genes

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英文摘要
The assembly of functional antigen receptor genes in lymphoid cells (generally known as V (D)j recombination) is known to depend on the products of the RAG-1 and RAG-2 genes, but it has not been clear whether these proteins act directly in recombination or whether they are indirect activators. Recombination is known to begin with a double st rand break in DNA, exactly at the border between each coding segment and its neighboring recombination signal sequence. We have now succeeded in reproducing this specific breakage step in a cell-free reaction requiring only the purified RG-1 and RAG-2 proteins. Thus RAG-1 and RAG-2 act directly in V(D)J recombination, and contain all the information for the site specificity of the reaction.
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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