STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
批准号:
3776322
负责人:
M GELLERT
金额:
$0.0万
依托单位国家:
美国
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财政年份:
--
资助国家:
美国
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至
中文摘要
我们在抗原受体基因重排(V(D)J
重组)描述了一种类型的断裂DNA分子,
在这个过程中的中间体。 这些分子,
T细胞受体δ基因座(TCR)仅具有含有
重组信号序列
我们现在也能够找到断裂的分子,
编码序列,但只有在DNA与scid突变,
干扰这些端部的连接。发现编码末端
有一个异常的结构:两条DNA链彼此相连
发夹结构。发夹的存在提供了一个很好的
免疫球蛋白和T细胞受体中观察结果的解释
编码接头,在形成过程中形成的自互补序列
重组 如果发夹结构偏离中心,
自然会产生互补插入。
这些结果加强了断裂-团聚模型的证据,
V(D)J复合,也表明该过程必须
与之前的例子不同。
英文摘要
Our earlier work on antigen receptor gene rearrangement (V(D)J
recombination) described one type of broken DNA molecules that were
plausible intermediates in this process. These molecules, seen at the
T cell receptor delta locus (TCR), had only the free end containing the
recombination signal sequence.
We have now also been able to find broken molecules with the end of the
coding sequence, but only in DNA from mice with the scid mutation, which
interferes with the joining of these ends. The coding ends are found to
have an abnormal structure: the two DNA strands are linked to each other
in a hairpin configuration.The presence of hairpins offers a good
explanation for the observation, in immunoglobulin and T cell receptor
coding junctions, of self- complementary sequences formed during
recombination. If a hairpin structure is nicked off-center, a self-
complementary insertion will naturally result.
These results strengthen the evidence for a breakage-reunion model of
V(D)J recombination, but also indicate that the process must be
different from earlier examples of this type.
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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批准号:3897281
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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批准号:3940667
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负责人:M GELLERT
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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批准号:3917766
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EFFECTS OF DNA SUPERCOILING ON THE TOPOLOGICAL PROPERTIES OF NUCLEOSOMES
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批准号:3917767
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负责人:M GELLERT
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STUDIES OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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批准号:3754209
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STUDIES OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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批准号:6161956
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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批准号:6161957
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STUDIES OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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STUDY OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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批准号:4689714
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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批准号:3964502
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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STUDIES OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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批准号:3854834
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STUDIES OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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批准号:6105239
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STUDY OF FUNCTIONS INVOLVED IN GENETIC RECOMBINATION
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批准号:3917765
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STUDIES OF IMMUNOGLOBULIN GENE REARRANGEMENT
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