课题基金 / 基金详情

MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION

MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
淋巴细胞功能的分子遗传学分析
批准号：
3768785
负责人：
D H MARGULIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768785
关键词：
MHC class I antigen T cell receptor antigen presentation human immunodeficiency virus 1 lymphocyte molecular genetics natural killer cells protein engineering proteolysis tissue /cell culture virus protein

项目摘要

项目成果

D H MARGULIES的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The focus of these studies has been on the functional role of the MHC class I molecule and the development of model systems for examining this function in vitro. Specific accomplishments during the past year include: 1) the characterization of proteolytic pathways involved in the extracellular processing of different class I restricted peptides; 2) the characterization of the minimal peptides derived from the HIV-1 gp 160 envelope glycoprotein that are presented by both H-2Dd and I-Ad; 3) the biochemical and functional analysis of a set of single chain class I molecules generated by engineering techniques; 4) the evaluation of the role of the MHC class I molecule H-2Dd in the signalling of a subset of NK cells bearing the cell surface marker Ly-49; 5) the evaluation of T cell receptor/class I interactions.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
BINDING OF PEPTIDES TO MHC MOLECULES
海外基金